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Altered glutamate uptake in peripheral tissues from Down syndrome patients
- Source :
- Neuroscience letters. 343(2)
- Publication Year :
- 2003
-
Abstract
- Overexpression of APP and SOD induces beta-amyloid deposition and oxidative stress in Down syndrome (DS) patients. Both phenomena may impair glutamate transport and decreased glutamate uptake sites have been demonstrated in patient brains at autopsy. Since alterations of APP metabolism and oxidative damage are systemic, we investigated glutamate uptake in platelets and fibroblasts from DS patients to explore whether abnormalities in this process are inherent properties of DS cells and not secondary to neurodegeneration. Glutamate uptake was significantly decreased in platelets (P
- Subjects :
- Adult
Blood Platelets
Male
medicine.medical_specialty
Glutamic Acid
Trisomy
Biology
In Vitro Techniques
medicine.disease_cause
chemistry.chemical_compound
Internal medicine
medicine
Humans
Platelet
Neurotransmitter
Fibroblast
Skin
Dose-Response Relationship, Drug
Mosaicism
General Neuroscience
Neurodegeneration
Glutamate receptor
Glutamic acid
Fibroblasts
Middle Aged
medicine.disease
medicine.anatomical_structure
Endocrinology
chemistry
Biochemistry
Case-Control Studies
Blood Platelet
Female
Down Syndrome
Case-Control Studie
Oxidative stress
Human
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 343
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....3edf829cefa9822989a6e7e278462b98