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Genital Wart Recurrence Among Men Residing in Brazil, Mexico, and the United States
- Source :
- The Journal of Infectious Diseases. 219:703-710
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- Background Genital wart (GW) incidence is high among men. The percentage and rate at which subsequent GW events occur are understudied. The purpose of this study was to describe the rate of subsequent GWs, associated human papillomavirus (HPV) types, and time to subsequent GW event among unvaccinated men. Methods The study was nested within a multinational prospective HPV natural history study of men aged 18-70 years in the United States, Mexico, and Brazil, examined every 6 months for a median follow-up of 50.4 months. Subsequent GW events were defined as GWs detected after ≥16 weeks of the prior event. Results Forty-four percent of men experienced ≥1 GW following the initial episode. Men with ≥2 subsequent events were at highest risk of continued GW experiences, with as high as 10 postinitial GW events. The incidence rate of each subsequent GW increased with increasing events (incidence of first subsequent event was 13.1 vs 36.6/1000 person-months for the fourth event). The proportion of GWs among HPV-6 and/or -11-positive patients remained constant across events. Approximately 63%-69% were positive for ≥1 of the 9-valent HPV vaccine types. Conclusions These data highlight the high burden of GWs among men across the lifespan and the need for vaccination to prevent multiple GW episodes.
- Subjects :
- Adult
Male
0301 basic medicine
Adolescent
Sexual Behavior
Genital warts
Young Adult
Major Articles and Brief Reports
03 medical and health sciences
0302 clinical medicine
Recurrence
medicine
Humans
Immunology and Allergy
Prospective Studies
030212 general & internal medicine
Human papillomavirus
Mexico
Papillomaviridae
Aged
business.industry
Incidence
Incidence (epidemiology)
Middle Aged
medicine.disease
United States
Vaccination
030104 developmental biology
Infectious Diseases
Condylomata Acuminata
business
Brazil
Natural history study
Follow-Up Studies
Demography
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 219
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....3ed925b2b3ef9ecbe5adbd567410f9ea