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Modelling cell division and endoreduplication in tomato fruit pericarp
- Source :
- Journal of Theoretical Biology, 349, 32-43, Journal of Theoretical Biology 349 (2014)
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- In many developing plant tissues and organs, differentiating cells switch from the classical cell cycle to an alternative partial cycle. This partial cycle bypasses mitosis and allows for multiple rounds of genome duplication without cell division, giving rise to cells with high ploidy numbers. This partial cycle is referred to as endoreduplication. Cell division and endoreduplication are important processes for biomass allocation and yield in tomato. Quantitative trait loci for tomato fruit size or weight are frequently associated with variations in the pericarp cell number, and due to the tight connection between endoreduplication and cell expansion and the prevalence of polyploidy in storage tissues, a functional correlation between nuclear ploidy number and cell growth has also been implicated (karyoplasmic ratio theory). In this paper, we assess the applicability of putative mechanisms for the onset of endoreduplication in tomato pericarp cells via development of a mathematical model for the cell cycle gene regulatory network. We focus on targets for regulation of the transition to endoreduplication by the phytohormone auxin, which is known to play a vital role in the onset of cell expansion and differentiation in developing tomato fruit. We show that several putative mechanisms are capable of inducing the onset of endoreduplication. This redundancy in explanatory mechanisms is explained by analysing system behaviour as a function of their combined action. Namely, when all these routes to endoreduplication are used in a combined fashion, robustness of the regulation of the transition to endoreduplication is greatly improved.
- Subjects :
- Statistics and Probability
Cell division
functional-analysis
Biology
Models, Biological
Wiskundige en Statistische Methoden - Biometris
General Biochemistry, Genetics and Molecular Biology
Solanum lycopersicum
Gene Expression Regulation, Plant
Auxin
Cyclins
Endoreduplication
E2F
Mathematical and Statistical Methods - Biometris
Mitosis
Genetics
chemistry.chemical_classification
solanum-lycopersicon
Indoleacetic Acids
General Immunology and Microbiology
Cell growth
Applied Mathematics
anaphase-promoting complex
arabidopsis-thaliana trichomes
food and beverages
General Medicine
Cell cycle
PE&RC
WUR GTB Gewasfysiologie Management en Model
endocycle onset
fission yeast
transcriptional adapter protein
Cyclin-Dependent Kinases
E2F Transcription Factors
cyclin-dependent kinase
chemistry
Fruit
Modeling and Simulation
Ploidy
auxin
General Agricultural and Biological Sciences
Cell Division
f-box protein
Subjects
Details
- ISSN :
- 00225193
- Volume :
- 349
- Database :
- OpenAIRE
- Journal :
- Journal of Theoretical Biology
- Accession number :
- edsair.doi.dedup.....3ed8bf7b2a1ed5adb717a8b6eef2b6e5