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Obesity and Risk of Infection
- Source :
- Kaspersen, K A, Pedersen, O B, Petersen, M S, Hjalgrim, H, Rostgaard, K, Møller, B K, Juul-Sørensen, C, Kotzé, S, Dinh, K M, Erikstrup, L T, Sørensen, E, Thørner, L W, Burgdorf, K S, Ullum, H & Erikstrup, C 2015, ' Obesity and risk of infection : results from the danish blood donor study ', Epidemiology, vol. 26, no. 4, pp. 580-9 . https://doi.org/10.1097/EDE.0000000000000301
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- BACKGROUND: It is well known that obesity complicates the course of several diseases. However, it is unknown whether obesity affects the risk of infection among healthy individuals.METHODS: We included 37,808 healthy participants from the Danish Blood Donor Study, who completed a questionnaire on health-related items. Obesity was defined as a body mass index ≥ 30 kg/m. Infections among participants were identified by relevant ICD-10 codes in the Danish National Patient Register and Anatomical Therapeutic Chemical (ATC) codes in the Danish Prescription Register. Multivariable Cox proportional hazards analysis with age as the underlying timescale was used as the statistical model.RESULTS: During 113,717 person-years of observation, 1,233 participants were treated for infection at a hospital. Similarly, during 58,411 person-years of observation, 15,856 participants filled at least one prescription of antimicrobials. Obesity was associated with risk of hospital-based treatment for infection (women: hazard ratio [HR] = 1.5, 95% confidence interval [CI] = 1.1, 1.9; men: HR = 1.5, 95% CI = 1.2, 1.9). For specific infections, obesity was associated with increased risk of abscesses (both sexes), infections of the skin and subcutaneous tissue (men), and respiratory tract infections and cystitis (women). Similarly, obesity was associated with filled prescriptions of antimicrobials overall (women: HR = 1.22, 95% CI = 1.14, 1.30; men: HR = 1.23, 95% CI: 1.15, 1.33) and particularly with phenoxymethylpenicillin, macrolides, dicloxacillin and flucloxacillin, and broad-spectrum penicillins.CONCLUSIONS: In a large cohort of healthy individuals, obesity was associated with risk of infection. This result warrants further studies of metabolism and the immune response.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Epidemiology
Denmark
Blood Donors
Penicillins
Infections
Floxacillin
Body Mass Index
Cohort Studies
Danish
Young Adult
Sex Factors
Anti-Infective Agents
Risk Factors
Surveys and Questionnaires
Internal medicine
Cystitis
medicine
Humans
Dicloxacillin
Obesity
Young adult
Respiratory Tract Infections
Aged
Proportional Hazards Models
Proportional hazards model
business.industry
Incidence
Soft Tissue Infections
Risk of infection
Incidence (epidemiology)
Middle Aged
medicine.disease
Abscess
language.human_language
Anti-Bacterial Agents
Multivariate Analysis
Immunology
language
Penicillin V
Female
Macrolides
business
Body mass index
Cohort study
Subjects
Details
- ISSN :
- 10443983
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Epidemiology
- Accession number :
- edsair.doi.dedup.....3ed8b3824ea7076ece566cef0deedd34