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Avian Influenza A (H7N9) viruses isolated from patients with mild and fatal infection differ in pathogenicity and induction of cytokines
- Source :
- Microbial pathogenesis. 111
- Publication Year :
- 2017
-
Abstract
- Since 2013, a novel Influenza A (H7N9) virus strain has continued to circulate within poultry and causing human disease. Influenza A (H7N9) virus results in two types of infection: mild and severe. The different results of clinical findings may be related with host susceptibility and characteristics of the virus itself. In order to investigate potential pathogenesis of Influenza A (H7N9) virus, we performed pathogenecity and cytokines analysis of two isolates, A/Guangdong/6/2013 H7N9 virus (GD-6) from a patient with a mild infection, and A/Guangdong/7/2013 H7N9 virus (GD-7) from a patient with a fatal infection. We found that GD-7 replicated to higher levels than GD-6 in human peripheral blood mononuclear cells (PBMCs), lung tissues, and mice. Furthermore, GD-7 infection resulted in more severe lung damage in mice lung tissues than GD-6 infection. GD-7 elicited higher levels of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) than GD-6 did. In conclusion, GD-7 was more pathogenic and induced higher levels of proinflammatory cytokines than GD-6 did.
- Subjects :
- 0301 basic medicine
Male
Biology
medicine.disease_cause
Influenza A Virus, H7N9 Subtype
Virus Replication
Microbiology
Peripheral blood mononuclear cell
Virus
Proinflammatory cytokine
Pathogenesis
03 medical and health sciences
Mice
0302 clinical medicine
Influenza, Human
medicine
Influenza A virus
Animals
Humans
030212 general & internal medicine
Lung
Virulence
Interleukin-6
Tumor Necrosis Factor-alpha
Virology
Influenza A virus subtype H5N1
Mice, Inbred C57BL
030104 developmental biology
Infectious Diseases
Viral replication
Immunology
Mutation
Cytokines
Tumor necrosis factor alpha
Female
Subjects
Details
- ISSN :
- 10961208
- Volume :
- 111
- Database :
- OpenAIRE
- Journal :
- Microbial pathogenesis
- Accession number :
- edsair.doi.dedup.....3ed4b27433c4310ec94aeaf2e351a186