Antifungal Lock Therapy With Liposomal Amphotericin B: A Prospective Trial

Authors :: William McGhee
George V. Mazariegos
Michael Green
Judith M. Martin
Marian G. Michaels
Source :: Journal of the Pediatric Infectious Diseases Society. 5:80-84
Publication Year :: 2014
Publisher :: Oxford University Press (OUP), 2014.
Abstract: We conducted a prospective pilot study to evaluate the potential role of combined systemic antifungal and liposomal amphotericin B lock therapy in children with intestinal insufficiency with fungal catheter-related bloodstream infections whose central venous catheters had not been removed. Our results provide supportive evidence for the conduct of larger clinical trials to confirm the efficacy and safety of this approach.