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Transforming Growth Factor Beta Signaling in Cutaneous Wound Healing: Lessons Learned from Animal Studies
- Source :
- Advances in wound care. 2(5)
- Publication Year :
- 2013
-
Abstract
- Wound healing is a complex physiological process involving a multitude of growth factors, among which transforming growth factor beta (TGF-β) has the broadest spectrum of effects. Animal studies have provided key information on the mechanisms of TGF-β action in wound healing and have guided the development of therapeutic strategies targeting the TGF-β pathway to improve wound healing and scarring outcome.Development of tissue-specific expression systems for overexpression or knockout of TGF-β signaling pathway components has led to novel insight into the role of TGF-β signaling in wound healing. This work has also identified molecules that might serve as molecular targets for the treatment of pathological skin conditions such as chronic wounds and excessive scarring (fibrosis).Many of the mouse models with genetic alterations in the TGF-β signaling pathway develop an underlying skin abnormality, which may pose some limitations on the interpretation of wound-healing results obtained in these animals. Also, TGF-β's pleiotropic effects on many cell types throughout all phases of wound healing present a challenge in designing specific strategies for targeting the TGF-β signaling pathway to promote wound healing or reduce scarring.Further characterization of TGF-β signaling pathway components using inducible tissue-specific overexpression or knockout technology will be needed to corroborate results obtained in mouse models that display a skin phenotype, and to better understand the role of TGF-β signaling during distinct phases of the wound-healing process. Such studies will also provide a better understanding of how TGF-β mediates its autocrine, paracrine, and double paracrine effects on cellular responses
- Subjects :
- Pathology
medicine.medical_specialty
integumentary system
biology
Critical Review Articles
business.industry
Skin abnormality
Transforming growth factor beta
Critical Care and Intensive Care Medicine
Bioinformatics
medicine.disease
Fibrosis
Emergency Medicine
biology.protein
Medicine
Animal studies
Signal transduction
Cutaneous wound
business
Wound healing
Transforming growth factor
Subjects
Details
- ISSN :
- 21621918
- Volume :
- 2
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Advances in wound care
- Accession number :
- edsair.doi.dedup.....3ec0b7871e26f46552d5de7846a08f8a