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Transplantation of human islets without immunosuppression
- Source :
- Proceedings of the National Academy of Sciences. 110:19054-19058
- Publication Year :
- 2013
- Publisher :
- Proceedings of the National Academy of Sciences, 2013.
-
Abstract
- Significance Diabetes mellitus type 1 is an autoimmune disease that results in irreversible destruction of insulin-producing beta cells. Substantial advances have been made in beta cell replacement therapies over the last decades. However, lack of eligible donor organs and the need for chronic immunosuppression to prevent rejection critically limit a widespread application of these strategies. In this paper we present the clinical success of using a bioartificial pancreas for the transplantation of insulin-producing islets without affecting the immune system. In a patient with long-standing type-1 diabetes we could demonstrate persistent graft function and regulated insulin secretion without the need for immune-modulating medication. This strategy opens up avenues for more widespread and safe application of various cell-based therapies.
- Subjects :
- Male
medicine.medical_treatment
Cell
Islets of Langerhans Transplantation
Biology
chemistry.chemical_compound
Diabetes mellitus
medicine
Humans
Immunosuppression Therapy
Glucose tolerance test
geography
Multidisciplinary
geography.geographical_feature_category
Bioartificial Organs
C-Peptide
medicine.diagnostic_test
C-peptide
Pancreatic islets
Immunosuppression
Glucose Tolerance Test
Middle Aged
Biological Sciences
medicine.disease
Islet
Immunohistochemistry
Transplantation
Diabetes Mellitus, Type 1
Treatment Outcome
medicine.anatomical_structure
chemistry
Immunology
Diffusion Chambers, Culture
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....3eb73386c6493aa585031fc2709e25dd
- Full Text :
- https://doi.org/10.1073/pnas.1317561110