Back to Search Start Over

Transplantation of human islets without immunosuppression

Authors :
Andreas Reichel
Michele Solimena
Stefan R. Bornstein
Norman L. Block
Anja Steffen
Uriel Barkai
Barbara Ludwig
Clark K. Colton
Zohar Gendler
Ezio Bonifacio
Avi Rotem
Andrew V. Schally
Stefan Ludwig
Baruch Zimerman
Stephan Kersting
Source :
Proceedings of the National Academy of Sciences. 110:19054-19058
Publication Year :
2013
Publisher :
Proceedings of the National Academy of Sciences, 2013.

Abstract

Significance Diabetes mellitus type 1 is an autoimmune disease that results in irreversible destruction of insulin-producing beta cells. Substantial advances have been made in beta cell replacement therapies over the last decades. However, lack of eligible donor organs and the need for chronic immunosuppression to prevent rejection critically limit a widespread application of these strategies. In this paper we present the clinical success of using a bioartificial pancreas for the transplantation of insulin-producing islets without affecting the immune system. In a patient with long-standing type-1 diabetes we could demonstrate persistent graft function and regulated insulin secretion without the need for immune-modulating medication. This strategy opens up avenues for more widespread and safe application of various cell-based therapies.

Details

ISSN :
10916490 and 00278424
Volume :
110
Database :
OpenAIRE
Journal :
Proceedings of the National Academy of Sciences
Accession number :
edsair.doi.dedup.....3eb73386c6493aa585031fc2709e25dd
Full Text :
https://doi.org/10.1073/pnas.1317561110