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Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group UK, 2021.
-
Abstract
- Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions of both have yet to be fully understood. This study therefore investigated the effects of kahweol acetate and cafestol on human renal cancer ACHN and Caki-1 cells. Accordingly, the combination of kahweol acetate and cafestol administration synergistically inhibited cell proliferation and migration by inducing apoptosis and inhibiting epithelial–mesenchymal transition. Mechanistic dissection revealed that kahweol acetate and cafestol inhibited Akt and ERK phosphorylation. Moreover, kahweol acetate and cafestol downregulated the expression of not only C–C chemokine receptors 2, 5, and 6 but also programmed death-ligand 1, indicating their effects on the tumor microenvironment. Thus, kahweol acetate and cafestol may be novel therapeutic candidates for renal cancer considering that they exert multiple pharmacological effects.
- Subjects :
- Epithelial-Mesenchymal Transition
Science
Cafestol
Drug development
Apoptosis
Pharmacology
Coffee
Article
chemistry.chemical_compound
Chemokine receptor
Cell growth
Cell Movement
medicine
Tumor Cells, Cultured
Humans
Cell migration
Protein kinase B
Carcinoma, Renal Cell
Kahweol
Cell Proliferation
Tumor microenvironment
Multidisciplinary
Kidney Neoplasms
Gene Expression Regulation, Neoplastic
Renal cancer
chemistry
Cancer cell
Medicine
Diterpenes
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....3eb5d89d2283bf0d4dc0d6195268871a