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Expression profile of circulating microRNAs in the Correa pathway of progression to gastric cancer
- Source :
- United European gastroenterology journal. 6(5)
- Publication Year :
- 2017
-
Abstract
- The purpose of this study was to explore the circulating-microRNA profile fromOne hundred and twenty-three patients were enrolled and assigned to the discovery or the validation sets. In the discovery phase, circulating-microRNAs were measured by dye-based quantitative polymerase chain reaction and a selection of circulating-microRNAs was validated by probe-based quantitative polymerase chain reaction. A quality control protocol was used.One hundred and sixty-seven circulating-microRNAs were detected. Precursor lesions of gastric cancer and gastric cancer patients showed the downregulation of eight and five circulating-microRNAs, respectively. We further validated the deregulation of miR-196a-5p in precursor lesions of gastric cancer and the deregulation of miR-134-5p, miR-144-3p and miR-451a in gastric cancer. However, circulating-microRNAs exhibited moderate diagnostic performance due to the overlap of circulating-microRNA expression between non-cancer and cancer patients. miR-144-3p/miR-451a expression levels were correlated. Interestingly, these microRNAs are in 17q11.2, a site of rearrangements associated with gastric cancer.Circulating-microRNAs are deregulated in precancerous and gastric cancer patients but efforts are needed to improve their diagnostic accuracy.
- Subjects :
- 0301 basic medicine
biology
business.industry
Chronic Active
digestive, oral, and skin physiology
Gastroenterology
Cancer
Original Articles
Helicobacter pylori
biology.organism_classification
medicine.disease
digestive system diseases
03 medical and health sciences
Circulating MicroRNA
030104 developmental biology
0302 clinical medicine
Oncology
030220 oncology & carcinogenesis
Cancer research
Medicine
Gastritis
medicine.symptom
Risk factor
business
Subjects
Details
- ISSN :
- 20506406
- Volume :
- 6
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- United European gastroenterology journal
- Accession number :
- edsair.doi.dedup.....3eb14a0888b2cea5a59e652c3a70b635