Fatal necrotizing angiitis after sulfadimethoxine therapy presenting as anaphylactoid purpura

A fatal case of diffuse systemic necrotizing angiitis is described in a 14 year old boy presenting with Schonlein-Henoch purpura and developing renal failure. It is proposed that a long-acting sulfonamide (sulfamidethoxine) caused the disease, thus serving to reinforce previously published warnings against the indiscriminate use of long-acting sulfonamides.