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Expression of cytokeratin 34βE12 is a good indicator of tumor progression in esophageal squamous cell carcinoma
- Source :
- Biomedical research (Tokyo, Japan). 33(3)
- Publication Year :
- 2012
-
Abstract
- Esophageal squamous cell carcinoma (ESCC) is considered one of the most aggressive cancers with poor prognosis. The high molecular weight cytokeratin 34βE12 (CK34βE12) is recognized by the antibody, that is expressed in the cytoplasm of epithelial basal cells, and has been considered as a potential marker for prostate cancer, breast cancer, and basaloid carcinoma of the lung. However, there are no clinicopathological studies investigating CK34βE12 expression at the invasive front of ESCC. In this study, we examined 170 surgically resected cases of ESCC to clarify the clinicopathological significance of CK34βE12 expression. CK34βE12 expression was found in 85.3% (145/170) of ESCC cases and was significantly correlated with lymph node metastasis (66.2% [96/145], P = 0.034), depth of tumor invasion (57.9% [84/145], P = 0.042), and differentiation (82.1% [119/145], P = 0.013). These results indicated that CK34βE12 expression is a good indicator of lymph node metastasis, depth of tumor invasion, and differentiation in case of ESCC.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
Esophageal Neoplasms
General Biochemistry, Genetics and Molecular Biology
Cytokeratin
Basal (phylogenetics)
Prostate cancer
Breast cancer
Internal medicine
Carcinoma
medicine
Humans
Aged
Neoplasm Staging
Aged, 80 and over
Lung
biology
business.industry
General Medicine
Middle Aged
medicine.disease
Prognosis
digestive system diseases
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
Tumor progression
Lymphatic Metastasis
biology.protein
Cancer research
Carcinoma, Squamous Cell
Disease Progression
Keratins
Female
Antibody
business
Subjects
Details
- ISSN :
- 1880313X
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biomedical research (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....3eab0173cc4a34ef909d1d6a4881b002