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Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective
- Source :
- Pharmacogenomics
- Publication Year :
- 2019
- Publisher :
- Future Medicine Ltd, 2019.
-
Abstract
- Clozapine is the only effective antipsychotic for treatment-resistant schizophrenia but remains widely under prescribed, at least in part due to its potential to cause agranulocytosis and neutropenia. In this article, we provide an overview of the current understanding of the genetics of clozapine-associated agranulocytosis and neutropenia. We now know that the genetic etiology of clozapine-associated neutropenia is complex and is likely to involve variants from several genes including HLA-DQB1, HLA-B and SLCO1B3/SLCO1B7. We describe recent findings relating to the Duffy-null genotype and its association with benign neutropenia in individuals with African ancestry. Further advances will come from sequencing studies, large, cross-population studies and in understanding the molecular mechanisms underlying these associations.
- Subjects :
- Neutropenia
Genotype
medicine.medical_treatment
Review
030226 pharmacology & pharmacy
agranulocytosis
03 medical and health sciences
Solute Carrier Organic Anion Transporter Family Member 1B3
0302 clinical medicine
Genetic etiology
Genetics
medicine
HLA-DQ beta-Chains
Humans
Antipsychotic
Clozapine
Genetic Association Studies
pharmacogenetics
Pharmacology
Future perspective
clozapine
business.industry
Benign neutropenia
medicine.disease
3. Good health
schizophrenia
Schizophrenia
HLA-B Antigens
030220 oncology & carcinogenesis
Molecular Medicine
business
Pharmacogenetics
medicine.drug
Antipsychotic Agents
Subjects
Details
- Language :
- English
- ISSN :
- 17448042 and 14622416
- Volume :
- 20
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pharmacogenomics
- Accession number :
- edsair.doi.dedup.....3eaa6772abf480409b60e4efb21bc6b0