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Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells
- Source :
- Ecotoxicology and Environmental Safety, Vol 208, Iss, Pp 111461-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Di-(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) are representative phthalic acid esters (PAEs), a class of environmental endocrine disruptors used as plasticizers. PAEs exposure is associated with glucose metabolism, insulin resistance, and glucose tolerance; however, the mechanism and various PAE effects on human glucose metabolism remain largely unknown. In this study, we investigated the effects of DEHP, DBP, and their mixture on rat insulinoma (INS-1) cell apoptosis and the mechanism involved in vitro. The INS-1 cells were cultured in RPMI-1640 + 10% fetal bovine serum for 24 h and pretreated with dimethyl sulfoxide (vehicle
- Subjects :
- endocrine system
animal structures
Cell Survival
Dibutyl phthalate
Health, Toxicology and Mutagenesis
Phthalic Acids
0211 other engineering and technologies
Apoptosis
02 engineering and technology
010501 environmental sciences
01 natural sciences
Environmental pollution
Phosphatidylinositol 3-Kinases
chemistry.chemical_compound
Insulin resistance
Plasticizers
medicine
Animals
GE1-350
PI3K/Akt/Bcl-2 signaling pathway
INS-1 cells
Protein kinase B
PI3K/AKT/mTOR pathway
0105 earth and related environmental sciences
021110 strategic, defence & security studies
Public Health, Environmental and Occupational Health
Phthalate
Rat Insulinoma
Esters
General Medicine
medicine.disease
Pollution
Dibutyl Phthalate
Rats
Pancreatic Neoplasms
Environmental sciences
Phthalic acid
Glucose
Proto-Oncogene Proteins c-bcl-2
TD172-193.5
chemistry
Biochemistry
Insulinoma
Phosphatidylinositol 3-Kinase
Reactive Oxygen Species
Proto-Oncogene Proteins c-akt
Fetal bovine serum
Signal Transduction
Subjects
Details
- ISSN :
- 01476513
- Volume :
- 208
- Database :
- OpenAIRE
- Journal :
- Ecotoxicology and Environmental Safety
- Accession number :
- edsair.doi.dedup.....3e926ec44f5d6b65538f54ed9b21af75