Back to Search
Start Over
Impact of intracoronary injection of CD133+ bone marrow stem cells on coronary atherosclerotic progression in patients with STEMI: a COMPARE-AMI IVUS substudy
- Source :
- ResearcherID
- Publication Year :
- 2015
-
Abstract
- Objectives Adverse effects of intracoronary injection of stem cells on in-stent restenosis and atherosclerotic progression remain unclear. We sought to evaluate the adverse effects of intracoronary injection of CD133 cells on in-stent restenosis and atherosclerotic progression in the infarct-related and contralateral arteries using serial intravascular ultrasound (IVUS) analysis. Methods Baseline and 4-month follow-up IVUS images were obtained from 17 patients treated with intracoronary stem cell injection and 20 placebo patients after primary percutaneous coronary intervention in the COMPARE-AMI trial. In the infarct-related artery, the stented segment, 5 mm proximal and distal reference segments, and proximal and distal nonstented segments were analyzed every 1 mm; the entire segment of a contralateral artery was also analyzed every 1 mm. Results In the infarct-related artery analysis, the median percentage of in-stent neointimal hyperplasia (12.1 vs. 7.6%, P=0.95), the reduction in the minimum lumen area (MLA; -1.6 vs. -1.5 mm(2), P=0.97), and the MLA at follow-up (4.3 vs. 5.3 mm(2), P=0.21) were found to be similar between the stem cell and placebo groups. Changes in proximal and distal nonstented segment lumen areas and plaque burden were also similar between the stem cell and placebo groups; however, there was a decrease in the maximum arc of the attenuated plaque behind the stent from baseline to follow-up in the placebo group (P=0.004), but not in the stem cell group. In the contralateral artery, there were no differences in changes in MLA, plaque burden, or attenuated plaque between stem cell and placebo patients. Conclusion Intracoronary injection of CD133(+) bone marrow stem cells has no IVUS-detectable effect on neointimal hyperplasia or atherosclerosis progression in either infarct-related or contralateral arteries.
- Subjects :
- Male
Time Factors
medicine.medical_treatment
Myocardial Infarction
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Coronary artery disease
Electrocardiography
0302 clinical medicine
Restenosis
Intravascular ultrasound
030212 general & internal medicine
Myocardial infarction
AC133 Antigen
Prospective Studies
Neointimal hyperplasia
medicine.diagnostic_test
Hematopoietic Stem Cell Transplantation
General Medicine
Middle Aged
Coronary Vessels
Treatment Outcome
Injections, Intra-Arterial
Cardiology
Female
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
Lumen (anatomy)
Bone Marrow Cells
03 medical and health sciences
Double-Blind Method
Antigens, CD
Internal medicine
medicine
Humans
cardiovascular diseases
Ultrasonography, Interventional
Glycoproteins
business.industry
Percutaneous coronary intervention
Stent
medicine.disease
Atherosclerosis
Hematopoietic Stem Cells
Feasibility Studies
business
Peptides
Follow-Up Studies
Subjects
Details
- ISSN :
- 14735830
- Volume :
- 27
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Coronary artery disease
- Accession number :
- edsair.doi.dedup.....3e900b8f5a2f2528bbc3fdcbd73f4967