MYC multimers shield stalled replication forks from RNA polymerase

Authors :: Daniel Solvie
Apoorva Baluapuri
Leonie Uhl
Daniel Fleischhauer
Theresa Endres
Dimitrios Papadopoulos
Amel Aziba
Abdallah Gaballa
Ivan Mikicic
Ekaterina Isaakova
Celeste Giansanti
Jennifer Jansen
Marvin Jungblut
Teresa Klein
Christina Schülein-Völk
Hans Maric
Sören Doose
Markus Sauer
Petra Beli
Andreas Rosenwald
Matthias Dobbelstein
Elmar Wolf
Martin Eilers
Source :: Nature. 612:148-155
Publication Year :: 2022
Publisher :: Springer Science and Business Media LLC, 2022.
Abstract: Oncoproteins of the MYC family drive the development of numerous human tumours

Subjects :: Binding Sites
Multidisciplinary
Transcription, Genetic
Tumor Suppressor Proteins
Ubiquitin-Protein Ligases
Humans
DNA Breaks, Double-Stranded
DNA-Directed RNA Polymerases
RNA Polymerase II
RNA, Messenger
Promoter Regions, Genetic
Chromatin
S Phase

Tools