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Experimental approaches to the study of HIV-1 latency
- Source :
- Nature Reviews Microbiology. 5:95-106
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Viral latency is a reversibly non-productive state of infection that allows some viruses to evade host immune responses. As a consequence of its tropism for activated CD4(+) T cells, HIV-1 can establish latent infection in resting memory CD4(+) T cells, which are generated when activated CD4(+) T cells return to a quiescent state. Latent HIV-1 persists as a stably integrated but transcriptionally silent provirus. In this state, the virus is unaffected by immune responses or antiretroviral drugs, and this latent reservoir in resting CD4(+) T cells is a major barrier to curing the infection. Unfortunately, there is no simple assay to measure the number of latently infected cells in a patient, nor is there an entirely representative in vitro model in which to explore the molecular mechanisms of latency. This Review will consider current approaches to the analysis of HIV-1 latency both in vivo and in vitro.
- Subjects :
- CD4-Positive T-Lymphocytes
General Immunology and Microbiology
Virus Integration
HIV Infections
Provirus
Biology
medicine.disease
Microbiology
Virology
In vitro
Virus
Virus Latency
Infectious Diseases
Immune system
Proviruses
In vivo
Immunology
Virus latency
HIV-1
medicine
Humans
Latency (engineering)
Immunologic Memory
Cells, Cultured
Tropism
Subjects
Details
- ISSN :
- 17401534 and 17401526
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Microbiology
- Accession number :
- edsair.doi.dedup.....3e7d2733dd69d51684df5a1f758a1596