Back to Search
Start Over
Carvedilol protected diabetic rat hearts via reducing oxidative stress
- Source :
- Journal of Zhejiang University SCIENCE B. 7:725-731
- Publication Year :
- 2006
- Publisher :
- Zhejiang University Press, 2006.
-
Abstract
- Oxidative stress plays a dominant role in the pathogenesis of diabetes mellitus. Bcl-2 gene has close connection with antioxidant stress destruction in many diseases including diabetes. Carvedilol, an adrenoceptor blocker, also has antioxidant properties. To study the effect of carvedilol on the antioxidant status in diabetic hearts, we investigated carvedilol-administrated healthy and streptozotocin-induced diabetic rats. After small and large dosage carvedilol-administered for 5 weeks, hemodynamic parameters, the levels of malondialdehyde, activities of antioxidant enzymes and expression of Bcl-2 mRNA in the cardiac tissues were measured. The diabetic rats not only had cardiac disfunction, weaker activities of antioxidant enzymes, but also showed lower expression of Bcl-2. Carvedilol treatment increased activities of antioxidant enzymes and expression of Bcl-2 in healthy rats as well as diabetic rats. These results indicated that carvedilol partly improves cardiac function via its antioxidant properties in diabetic rats.
- Subjects :
- Blood Glucose
Male
Cardiac function curve
medicine.medical_specialty
Antioxidant
Systole
medicine.medical_treatment
Carbazoles
medicine.disease_cause
Antioxidants
Streptozocin
General Biochemistry, Genetics and Molecular Biology
Diabetes Mellitus, Experimental
Propanolamines
Rats, Sprague-Dawley
Pathogenesis
chemistry.chemical_compound
Malondialdehyde
Internal medicine
Diabetes mellitus
medicine
Animals
Myocyte
Myocytes, Cardiac
RNA, Messenger
General Pharmacology, Toxicology and Pharmaceutics
Carvedilol
General Veterinary
Reverse Transcriptase Polymerase Chain Reaction
business.industry
Body Weight
Heart
General Medicine
medicine.disease
Rats
Biomedicine
Oxidative Stress
Endocrinology
Proto-Oncogene Proteins c-bcl-2
chemistry
business
Oxidative stress
medicine.drug
Subjects
Details
- ISSN :
- 18621783 and 16731581
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Zhejiang University SCIENCE B
- Accession number :
- edsair.doi.dedup.....3e659d8d727a0211628230587363afbc