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Genetic Risk Surveillance for Invasive Aspergillosis in Hematology Patients: A Prospective Observational Study
- Source :
- Infectious Diseases and Therapy, Vol 9, Iss 4, Pp 807-821 (2020), Infectious Diseases and Therapy
- Publication Year :
- 2020
- Publisher :
- Adis, Springer Healthcare, 2020.
-
Abstract
- Introduction The association between genetic background and the risk of invasive aspergillosis (IA) has not been addressed in Thailand. We conducted genetic risk surveillance for IA among Thai hematologic patients. Methods We conducted a prospective observational cohort study including moderate- to high-risk hematology patients at Ramathibodi Hospital. IA occurrence, relevant clinical data, and genetic analyses were assessed. Odds ratios (ORs) of IA were assessed for the presence of the selected single nucleotide polymorphism genotype using logistic regression. Results A total of 357 patients were enrolled. The most common hematologic disease was non-Hodgkin lymphoma (45.1%). IA was diagnosed in 36 patients (10.10%). The C allele of IL10rs1800896 was associated with an increased risk of IA (adjusted OR 5.297; 95% confidence interval [CI] 2.032–13.809, p = 0.001). In multivariate Cox regression analysis, prolonged neutropenia and the C allele of IL10rs1800896 were associated with IA (hazard ratio [HR] 12.585; 95% CI 3.866–40.967, p < 0.001 and HR 2.449; 95% CI 1.097–5.468, p = 0.042, respectively). Conclusions Carrying the C allele of IL10rs1800896 was associated with an increased risk of IA among moderate- to high-risk Thai patients with hematologic diseases. This finding can potentially lead to a novel risk stratification scheme to further prevent IA in resource-limited settings. Electronic supplementary material The online version of this article (10.1007/s40121-020-00331-4) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Hematology patients
030106 microbiology
Single-nucleotide polymorphism
Infectious and parasitic diseases
RC109-216
Neutropenia
03 medical and health sciences
0302 clinical medicine
Internal medicine
Genetic predisposition
Genetic susceptibility
Medicine
030212 general & internal medicine
Original Research
business.industry
Proportional hazards model
Hazard ratio
Odds ratio
medicine.disease
Infectious Diseases
Hematologic disease
Invasive aspergillosis
Antifungal prophylaxis
business
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 21936382 and 21938229
- Volume :
- 9
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Infectious Diseases and Therapy
- Accession number :
- edsair.doi.dedup.....3e45c49b0260fb40f8cc62e62f8be61f