Hydration releases inhibition of feeding produced by intracranial angiotensin

A 10 ng dose of angiotensin injected into the lateral preoptic area of the brain induces drinking and suppresses feeding in 24 hr food-deprived rats. The induction of drinking is reduced, and the suppression of feeding abolished, by a 15 ml intragastric preload of water, or of isotonic saline. The results are interpreted as showing that suppression of feeding by angiotensin is due to inhibition of feeding by a central thirst factor.