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Early intervention in psoriasis and immune-mediated inflammatory diseases: A hypothesis paper
- Source :
- Journal of Dermatological Treatment, 26, 103-12, Journal of Dermatological Treatment, 26, 2, pp. 103-12
- Publication Year :
- 2015
-
Abstract
- Contains fulltext : 155098.pdf (Publisher’s version ) (Open Access) Psoriasis is an immune-mediated inflammatory disease (IMID) which may have a major impact on a patient's life, especially when the disease is moderate to severe. There is evidence that treatment of psoriasis during the first years is conservative and frequently based on topical agents which rarely clear lesions. Treatment with systemic agents including biologics is often undertaken only when topical agents have proved unsuitable, even in patients with moderate to severe disease. However, there is evidence that in other IMIDs (rheumatoid arthritis and Crohn's disease), targeted systemic treatment given early in the treatment pathway may improve long-term patient outcomes. We hypothesize that a patient-centered therapeutic approach, undertaken early in the psoriasis treatment pathway ("early intervention") with the goal of complete clearance, may improve control of cutaneous symptoms and may also modify disease course and burden. Critical points to address when designing an early intervention study would include: the definition of psoriasis disease activity; patient selection; intervention selection; and dosing strategies.
- Subjects :
- medicine.medical_specialty
Dermatology
Disease
Comorbidities
early intervention
management
pathophysiology
psoriasis
Arthritis, Rheumatoid
030207 dermatology & venereal diseases
03 medical and health sciences
Therapeutic approach
0302 clinical medicine
Crohn Disease
Psoriasis
Intervention (counseling)
Humans
Medicine
Dosing
Intensive care medicine
030304 developmental biology
0303 health sciences
business.industry
medicine.disease
Pathophysiology
3. Good health
Rheumatoid arthritis
Disease Progression
Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5]
Physical therapy
Immune-mediated inflammatory diseases
business
Subjects
Details
- ISSN :
- 09546634
- Database :
- OpenAIRE
- Journal :
- Journal of Dermatological Treatment, 26, 103-12, Journal of Dermatological Treatment, 26, 2, pp. 103-12
- Accession number :
- edsair.doi.dedup.....3e2997e8dffc63a25c01a62324ce8f96