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4-Methyl-5-phenyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I
- Source :
- Bioorganicmedicinal chemistry letters. 18(11)
- Publication Year :
- 2008
-
Abstract
- 4-Methyl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They were active in vitro and in an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.
- Subjects :
- Models, Molecular
Stereochemistry
Ratón
Clinical Biochemistry
Pharmaceutical Science
Dehydrogenase
Biochemistry
Chemical synthesis
Isozyme
Sulfone
chemistry.chemical_compound
Mice
Structure-Activity Relationship
In vivo
Drug Discovery
11-beta-Hydroxysteroid Dehydrogenase Type 1
Animals
Combinatorial Chemistry Techniques
Humans
Enzyme Inhibitors
Molecular Biology
chemistry.chemical_classification
Molecular Structure
Chemistry
Organic Chemistry
Triazoles
In vitro
Disease Models, Animal
Enzyme
Molecular Medicine
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 18
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....3e296e9eb774987308ea32068fac15de