The state of the art of membrane protein structure prediction: from sequence to 3D structure

Authors :: G. von Heijne
Rita Casadio
Andrea Pierleoni
Piero Fariselli
Pier Luigi Martelli
Ivan Rossi
FRISHMAN D, VALENCIA A
Casadio R.
Fariselli P.
Martelli P.L.
Pierleoni A.
Rossi I.
von Heijne G.
Source :: Modern Genome Annotation ISBN: 9783211751220
Publication Year :: 2008
Publisher :: Springer, 2008.
Abstract: 1. Why membrane proteins? 2 Many functions 3 Bioinformatics and membrane proteins: is it feasible to predict the 3D structure of a membrane protein? 4 Predicting the topology of membrane proteins 5 How many methods to predict membrane protein topology? 5.1 From theory to practice 6 Benchmarking the predictors of transmembrane topology 6.1 Testing on membrane proteins of known structure and topology 6.2 Topological experimental data 6.3 Validation towards experimental data 7 How many membrane proteins in the Human genome? 8 Membrane proteins and genetic diseases: PhD-SNP at work 9 Last but not least: 3D MODELLING of membrane proteins 10 What can currently be done in practice? 11 Can we improve?

Subjects :: Chemistry
Sequence (biology)
Hide markov model
Computational biology
Protein structure prediction
Genome
Transmembrane domain
Membrane protein
Proteome
PREDICTION OF THE STRUCTURE OF MEMBRANE PROTEINS
MACHINE LEARNING METHODS
PREDICTION OF THE TOPOGRAPHY OF MEMBRANE PROTEINS
Organism
MEMBRANE PROTEINS

Tools