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Therapeutic efficacy of ranitidine bismuth citrate with clarithromycin for seven days in the eradication of Helicobacter pylori in Brazilian peptic ulcer patients
- Source :
- Sao Paulo Medical Journal v.121 n.1 2003, São Paulo medical journal, Associação Paulista de Medicina, instacron:APM, Sao Paulo Medical Journal, Volume: 121, Issue: 1, Pages: 15-18, Published: 2003, São Paulo Medical Journal, Vol 121, Iss 1, Pp 15-18
- Publication Year :
- 2003
- Publisher :
- Associação Paulista de Medicina - APM, 2003.
-
Abstract
- CONTEXT: The curative treatment of peptic ulcer is made available nowadays through the eradication of the bacterium Helicobacter pylori, which is associated with it, but the best therapeutic regimen is yet to be determined. OBJECTIVE: To assess the efficacy of a therapeutic regimen with 400 mg ranitidine bismuth citrate associated with 500 mg clarithromycin given twice a day for seven days in a cohort of Brazilian patients with peptic ulcer. TYPE OF STUDY: Cross-sectional study. SETTING: Tertiary-care hospital. PATIENTS: One hundred and twenty nine outpatients, with active or healed peptic ulcers infected by Helicobacter pylori, diagnosed via endoscopy with confirmation via the urease test and histological examination, who had never undergone a regimen for the eradication of the bacterium. PROCEDURE: Administration of 400 mg ranitidine-bismuth and 500 mg clarithromycin twice a day, for seven days. MAIN MEASUREMENTS: Efficacy of the treatment, with a check on the cure done via another endoscopy eight weeks after drug administration. The eradication of the bacterium was determined via the urease test and histological examination. Patients who were negative for both were considered to be cured. RESULTS: Eight patients failed to complete the study. The eradication rate according to intention to treat was 81% (104/129) and per protocol was 86% (104/121). CONCLUSION: The bismuth ranitidine compound associated with clarithromycin used for one week was shown to be a simple, effective and well-tolerated therapeutic regimen for the eradication of Helicobacter pylori. CONTEXTO: O tratamento curativo da úlcera péptica é proporcionado atualmente pela erradicação da bactéria Helicobacter pylori, a ela associada, mas o melhor esquema de erradicação ainda não está determinado. OBJETIVO: Avaliar a eficácia de um esquema terapêutico com citrato de bismuto ranitidina 400 mg associado a claritromicina 500 mg, ministrados duas vezes ao dia por sete dias em uma população de ulcerosos brasileiros. TIPO DE ESTUDO: Estudo transversal. LOCAL: hospital de atenção terciária. PARTICIPANTES: 129 pacientes ambulatoriais, portadores de úlcera péptica ativa ou cicatrizada, diagnosticados por endoscopia e com infecção pelo Helicobacter pylori confirmada pelo teste da urease e exame histológico, que nunca foram submetidos a tratamento para erradicação da bactéria. PROCEDIMENTO: Administração dos medicamentos citrato de bismuto ranitidina 400 mg e claritromicina 500 mg duas vezes ao dia, durante sete dias. VARIÁVEIS ESTUDADAS: Eficácia de tratamento com o controle de cura em nova endoscopia realizada oito semanas após o uso dos medicamentos. A erradicação da bactéria foi determinada pelo teste da urease e por histologia, sendo considerados curados os pacientes com resultados negativos para os dois exames. RESULTADOS: Oito pacientes não completaram o estudo. O índice de erradicação por intenção de tratamento foi de 81% (104/129) e por protocolo, 86% (104/121). CONCLUSÃO: O composto bismuto-ranitidina, associado à claritromicina, utilizado por uma semana, mostrou ser um esquema bastante simples, eficaz e bem tolerado para a erradicação do Helicobacter pylori.
- Subjects :
- Adult
Male
Peptic Ulcer
medicine.medical_specialty
Adolescent
Bismuto
Peptic
Rapid urease test
lcsh:Medicine
Context (language use)
Ranitidine
Gastroenterology
Drug Administration Schedule
Helicobacter Infections
Clarithromycin
Internal medicine
medicine
Humans
Peptic ulcer treatment
Aged
Eradication
Intention-to-treat analysis
biology
Úlcera péptica tratamento
Helicobacter pylori
business.industry
lcsh:R
General Medicine
Middle Aged
Anti-Ulcer Agents
biology.organism_classification
Anti-Bacterial Agents
Regimen
Cross-Sectional Studies
Erradicação
Clarithromycin therapeutic use
Ranitidine-bismuth
Drug Therapy, Combination
Female
business
Bismuth
Brazil
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Sao Paulo Medical Journal v.121 n.1 2003, São Paulo medical journal, Associação Paulista de Medicina, instacron:APM, Sao Paulo Medical Journal, Volume: 121, Issue: 1, Pages: 15-18, Published: 2003, São Paulo Medical Journal, Vol 121, Iss 1, Pp 15-18
- Accession number :
- edsair.doi.dedup.....3e1da42241ad7104437d90fa8d02bb1d