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Thrombophilia testing in patients with portal vein thrombosis
- Source :
- Kirkeby, M H, Larsen, J B, Grønbaek, H & Hvas, A-M 2020, ' Thrombophilia testing in patients with portal vein thrombosis ', Scandinavian Journal of Clinical and Laboratory Investigation, vol. 80, no. 8, pp. 694-698 . https://doi.org/10.1080/00365513.2020.1827289
- Publication Year :
- 2020
- Publisher :
- Informa UK Limited, 2020.
-
Abstract
- Portal vein thrombosis (PVT) is a rare but severe condition. Several risk factors predispose to PVT. However, it remains unclear to which degree thrombophilia contributes to the risk of PVT and whether PVT patients should be routinely referred for thrombophilia testing. The aim of the present study was to investigate the prevalence of thrombophilia in PVT patients to clarify the relevance of thrombophilia testing in PVT patients. Clinical data and results from thrombophilia investigations were systematically obtained from all PVT patients referred to Centre for Hemophilia and Thrombosis, Aarhus University Hospital, Denmark for thrombophilia testing between 1st of January 2010 and 31st of December 2018 (n = 93). The investigated thrombophilias included factor V Leiden and prothrombin G20210A mutations, deficiency of protein S, protein C and antithrombin, antiphospholipid syndrome, and increased levels of factor VIII. The prevalence of thrombophilia was compared to healthy controls obtained from previously published data on thrombophilia distribution in cohorts of the Western European adult general population. Comparing PVT patients with healthy controls, significantly increased odds of presence of lupus anticoagulant (crude odds ratio (OR) 6.2, 95% confidence interval (CI) 1.8–20.6) were found, whereas no significantly increased odds of inherited thrombophilia were demonstrated. In conclusion, routine testing for inherited thrombophilia in PVT patients does not seem indicated. However, PVT patients should still be tested for antiphospholipid antibodies because patients meeting the criteria for antiphospholipid syndrome preferentially should receive vitamin K antagonists as anticoagulant therapy.
- Subjects :
- Adult
Male
medicine.medical_specialty
Cirrhosis
genetic structures
Denmark
Clinical Biochemistry
Portal vein
030204 cardiovascular system & hematology
Thrombophilia
behavioral disciplines and activities
Antithrombins
Protein S
03 medical and health sciences
0302 clinical medicine
Internal medicine
mental disorders
Prevalence
medicine
Humans
In patient
Venous Thrombosis
Factor VIII
Portal Vein
business.industry
Anticoagulants
Factor V
Protein C Deficiency
General Medicine
Middle Aged
Antiphospholipid Syndrome
medicine.disease
Portal vein thrombosis
Venous thrombosis
Case-Control Studies
Lupus Coagulation Inhibitor
Mutation
Cardiology
Female
Prothrombin
030211 gastroenterology & hepatology
business
human activities
psychological phenomena and processes
Protein C
Subjects
Details
- ISSN :
- 15027686 and 00365513
- Volume :
- 80
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Clinical and Laboratory Investigation
- Accession number :
- edsair.doi.dedup.....3e1d613dd6ae350f557a99216c8f1fea