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Mind the gap: delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors

Authors :
Arjan Blokland
Jos Prickaerts
Sven Akkerman
Neuropsychology & Psychopharmacology
Psychiatrie & Neuropsychologie
RS: FPN NPPP II
Source :
Neurobiology of Learning and Memory, 109, 139-143. Elsevier Science
Publication Year :
2013

Abstract

We examined the temporal profile of pharmacologically enhanced episodic memory, using the object recognition task. Male Wistar rats were tested at different retention intervals ranging from 1 h to 24 h. The object discrimination performance of all groups (untreated, placebo, drug treatment) gradually decreased up to an interval (8 h). Interestingly, only after this 8 h interval the memory improving effects of vardenafil and rolipram started to emerge. This time-dependent memory performance shows similarities with the Kamin effect. The delayed manifestation of drug-enhanced memory suggests that two separate memory mechanisms are at play, a quick transient form of memory and a more stable memory form that requires several hours to develop. It is important to take this into account when testing treatments intended for long-term memory enhancement.

Details

ISSN :
10959564 and 10747427
Volume :
109
Database :
OpenAIRE
Journal :
Neurobiology of learning and memory
Accession number :
edsair.doi.dedup.....3e15078b4f686e01a145867cc57a8306