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Mind the gap: delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors
- Source :
- Neurobiology of Learning and Memory, 109, 139-143. Elsevier Science
- Publication Year :
- 2013
-
Abstract
- We examined the temporal profile of pharmacologically enhanced episodic memory, using the object recognition task. Male Wistar rats were tested at different retention intervals ranging from 1 h to 24 h. The object discrimination performance of all groups (untreated, placebo, drug treatment) gradually decreased up to an interval (8 h). Interestingly, only after this 8 h interval the memory improving effects of vardenafil and rolipram started to emerge. This time-dependent memory performance shows similarities with the Kamin effect. The delayed manifestation of drug-enhanced memory suggests that two separate memory mechanisms are at play, a quick transient form of memory and a more stable memory form that requires several hours to develop. It is important to take this into account when testing treatments intended for long-term memory enhancement.
- Subjects :
- Male
Memory, Long-Term
Phosphodiesterase Inhibitors
Cognitive Neuroscience
Memory, Episodic
Phosphodiesterase
Experimental and Cognitive Psychology
Recognition, Psychology
Placebo
Object (computer science)
Term (time)
Rats
Behavioral Neuroscience
Vardenafil
Memory improvement
medicine
Animals
Rats, Wistar
Psychology
Neuroscience
Episodic memory
Rolipram
medicine.drug
Subjects
Details
- ISSN :
- 10959564 and 10747427
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Neurobiology of learning and memory
- Accession number :
- edsair.doi.dedup.....3e15078b4f686e01a145867cc57a8306