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Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
- Source :
- Viruses, Viruses, Vol 11, Iss 1, p 60 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) of the S protein contains a critical neutralizing domain and is an important target for development of MERS vaccines and therapeutics. In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy.
- Subjects :
- 0301 basic medicine
viruses
lcsh:QR1-502
Review
Computational biology
Antibodies, Viral
medicine.disease_cause
spike protein
Antiviral Agents
Viral infection
Genome
lcsh:Microbiology
Domain (software engineering)
Mice
03 medical and health sciences
MERS-CoV
Drug Delivery Systems
0302 clinical medicine
Chiroptera
Virology
medicine
therapeutics
Animals
Humans
030212 general & internal medicine
Infectious virus
Coronavirus
Binding Sites
biology
Spike Protein
virus diseases
Viral Vaccines
vaccines
medicine.disease
Antibodies, Neutralizing
3. Good health
030104 developmental biology
Infectious Diseases
Spike Glycoprotein, Coronavirus
Middle East Respiratory Syndrome Coronavirus
biology.protein
Receptors, Virus
Middle East respiratory syndrome
Antibody
receptor-binding domain
Coronavirus Infections
Protein Binding
Subjects
Details
- ISSN :
- 19994915
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....3e09123c7fe1e319fe28c55eafff3c80
- Full Text :
- https://doi.org/10.3390/v11010060