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Changes in Bone Mass After Discontinuation of Preexposure Prophylaxis With Tenofovir Disoproxil Fumarate/Emtricitabine in Young Men Who Have Sex With Men: Extension Phase Results of Adolescent Trials Network Protocols 110 and 113
- Source :
- Clin Infect Dis
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Human immunodeficiency virus–seronegative men aged 15–22 years who lost bone mineral density (BMD) during tenofovir disoproxil fumarate/emtricitabine preexposure prophylaxis (PrEP) showed BMD recovery 48 weeks following PrEP discontinuation. Lumbar spine and whole body BMD z-scores remained below baseline 48 weeks off PrEP in participants aged 15–19 years.Clinical Trials Registration. NCT01772823 (ATN 110) and NCT01769456 (ATN 113).
- Subjects :
- Adult
Male
musculoskeletal diseases
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Adolescent
Tenofovir
Anti-HIV Agents
Human immunodeficiency virus (HIV)
HIV Infections
Emtricitabine
medicine.disease_cause
Men who have sex with men
Sexual and Gender Minorities
Young Adult
03 medical and health sciences
Pre-exposure prophylaxis
0302 clinical medicine
Bone Density
Internal medicine
medicine
Humans
030212 general & internal medicine
Homosexuality, Male
Bone mineral
business.industry
030112 virology
Discontinuation
Clinical trial
Infectious Diseases
Pre-Exposure Prophylaxis
Brief Reports
business
medicine.drug
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....3e04c8e968523ffa63210b131e4acfdf