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Clinical and Immunological Profile of Anti-factor H Antibody Associated Atypical Hemolytic Uremic Syndrome: A Nationwide Database
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 10 (2019)
- Publication Year :
- 2019
- Publisher :
- Frontiers Media SA, 2019.
-
Abstract
- Background: Atypical hemolytic uremic syndrome (aHUS), an important cause of acute kidney injury (AKI), is characterized by dysregulation of the alternative complement pathway. Autoantibodies to factor H (FH), a chief regulator of this pathway, account for a distinct subgroup. While high anti-FH titers predict relapse, they do not correlate well with disease activity and their functional characterization is required.Methods: Of 781 patients
- Subjects :
- lcsh:Immunologic diseases. Allergy
0301 basic medicine
Male
medicine.medical_specialty
Thrombotic microangiopathy
Adolescent
Databases, Factual
medicine.medical_treatment
Immunology
Left ventricular hypertrophy
Gastroenterology
Autoantigens
03 medical and health sciences
0302 clinical medicine
Maintenance therapy
Internal medicine
plasma exchange
Atypical hemolytic uremic syndrome
medicine
renal reserve
Humans
Immunology and Allergy
Child
Autoantibodies
Original Research
Proteinuria
business.industry
atypical hemolytic uremic syndrome
Antibody titer
Acute kidney injury
Infant
Immunosuppression
medicine.disease
factor H
thrombotic microangiopathy
030104 developmental biology
Child, Preschool
Complement Factor H
Female
medicine.symptom
lcsh:RC581-607
business
Immunosuppressive Agents
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 16643224
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....3dee405d1e472257467d65e07b0c1b69
- Full Text :
- https://doi.org/10.3389/fimmu.2019.01282