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Effects of low dose radiation on immune cells subsets and cytokines in mice
- Source :
- Toxicol Res (Camb)
- Publication Year :
- 2020
- Publisher :
- Oxford University Press, 2020.
-
Abstract
- Whole-body exposure to low-dose radiation due to diagnostic imaging procedures, occupational hazards and radiation accidents is a source of concern. In this study, we analyzed the effects of single and long-term low-dose irradiation on the immune system. Male Balb/c mice received a single whole-body dose of irradiation (0.01, 0.05, 0.2, 0.5 or 1 Gy). For long-term irradiation, mice were irradiated 10 times (total dose of 0.2, 0.5 or 1 Gy) over a period of 6 weeks. Two days after single or long-term irradiation, the numbers of splenic macrophages, natural killer cells and dendritic cells were reduced, and the spleen organ coefficient was decreased. At 2 Days after long-term low-dose irradiation, the number of white blood cells in the peripheral blood of the mice decreased. Between 7 and 14 Days after long-term low-dose irradiation, the number of immune cells in the thymus and spleen began to increase and then stabilized. Th1/Th2 cytokines and reactive oxygen species-related proteins first decreased and then increased to a plateau. Our results show a significant difference in the effects of single and long-term low-dose irradiation on the immune system.
- Subjects :
- Paper
0303 health sciences
Chemistry
Health, Toxicology and Mutagenesis
Significant difference
Spleen
Toxicology
Peripheral blood
Andrology
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Immune system
030220 oncology & carcinogenesis
Total dose
medicine
Irradiation
Radiation Accidents
030304 developmental biology
Low Dose Radiation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Toxicol Res (Camb)
- Accession number :
- edsair.doi.dedup.....3decc244bd92c08f7b14a6c76c3dc76c