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Investigation of Plantago ovata Husk as Pharmaceutical Excipient for Solid Dosage Form (Orodispersible Tablets)
- Source :
- BioMed Research International, BioMed Research International, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi, 2021.
-
Abstract
- The objective of the study was to investigate the suitability of the Plantago ovata (PO) husk as a pharmaceutical excipient. Various phytoconstituents of the husk were determined according to the standard test procedures. The Plantago ovata husk was evaluated for various pharmaceutical parameters related to flow, swelling index, and compressibility index. Orodispersible tablets (ODTs) were prepared, containing different concentrations (2.5, 3, 5, 7.5, 10, and 15% w / w ) of the Plantago ovata husk. Before compression, all the formulations were evaluated for their flow. Compressed ODTs were evaluated for physical characteristics (physical appearance, weight and weight variation, thickness, and moisture content), mechanical strength (crushing strength, specific crushing strength, tensile strength, and friability), disintegration behavior (disintegration time and oral disintegration time), drug content, and in vitro drug release. Phytochemical evaluation of the Plantago ovata husk confirmed the presence of various phytoconstituents like alkaloids, tannins, glycosides, saponins, flavonoids, and phenols. SEM photograph of the Plantago ovata husk showed that it has a fibrous structure, with a porous and rough surface. The Plantago ovata husk had a high swelling index (380%) which decreased by pulverization (310%). Precompression evaluation of the powder blend for all the formulations of ODTs showed good flow properties, indicating that the Plantago ovata husk improved the rheological characteristics of the powder blend. Compressed ODTs had good mechanical strength, and their friability was within the official limits ( w / w of the Plantago ovata husk. It is concluded that the Plantago ovata husk can be used as a disintegrant in the formulation of ODTs.
- Subjects :
- Dietary Fiber
Time Factors
Compressive Strength
Article Subject
Chemistry, Pharmaceutical
02 engineering and technology
Friability
Husk
General Biochemistry, Genetics and Molecular Biology
Dosage form
Plantago ovata
Excipients
020401 chemical engineering
X-Ray Diffraction
Tensile Strength
Ultimate tensile strength
medicine
Food science
0204 chemical engineering
Plantago
General Immunology and Microbiology
biology
Chemistry
04 agricultural and veterinary sciences
General Medicine
Saponins
biology.organism_classification
Drug Liberation
Compressive strength
Phytochemical
040103 agronomy & agriculture
Microscopy, Electron, Scanning
0401 agriculture, forestry, and fisheries
Medicine
Stress, Mechanical
Swelling
medicine.symptom
Powders
Porosity
Research Article
Tablets
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....3de9395382d602f441f08bb8e5f2b155
- Full Text :
- https://doi.org/10.1155/2021/5538075