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The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia

Authors :
Katarzyna Rek-Owodziń
Ernest Tyburski
Piotr Plichta
Katarzyna Waszczuk
Maksymilian Bielecki
Krzysztof Wietrzyński
Piotr Podwalski
Krzysztof Rudkowski
Anna Michalczyk
Tomasz Grąźlewski
Leszek Sagan
Jolanta Kucharska-Mazur
Jerzy Samochowiec
Monika Mak
Source :
Journal of Clinical Medicine; Volume 11; Issue 9; Pages: 2619
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological symptoms and cognitive functions. We recruited 32 patients with first-episode psychosis (FEP), 70 with chronic schizophrenia (CS), and 39 healthy controls (HC). Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions were measured with the MATRICS Cognitive Consensus Battery (MCCB). Cognitive deficits were present in both FEP and CS participants. CS individuals had lower overall scores and poorer working memory; however, clinical variables appeared to play a significant role in these scores. In FEP, disorganization correlated negatively with verbal and visual learning and memory, social cognition, and overall score; negative symptoms negatively correlated with social cognition. In CS participants, disorganization correlated negatively with speed of processing, reasoning, problem solving, and overall score; negative symptoms were negatively correlated with speed of processing, visual learning, memory, and overall score; positive symptoms were negatively correlated with reasoning and problem solving. Our findings indicate that psychopathological symptoms have a significant impact on cognitive functions in FEP and CS patients.

Details

ISSN :
20770383
Volume :
11
Database :
OpenAIRE
Journal :
Journal of Clinical Medicine
Accession number :
edsair.doi.dedup.....3de0fec199d6194e9ea3f628427bbf87
Full Text :
https://doi.org/10.3390/jcm11092619