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Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism
- Source :
- Theranostics
- Publication Year :
- 2017
- Publisher :
- Ivyspring International Publisher, 2017.
-
Abstract
- The weakened tumour colonization of attenuated Salmonella has severely hampered its clinical development. In this study, we investigated whether an anti-inflammation and antiangiogenesis compound triptolide could improve the efficacy of VNP20009, a highly attenuated Salmonella strain, against mice melanoma. By comparing the effects of conventional VNP20009 monotherapy and a combination therapy that uses both triptolide and VNP20009, we found that triptolide significantly improved the tumour colonization of VNP20009 by reducing the number of infiltrated neutrophils in the melanoma, which led to a larger necrotic area in the melanoma. Moreover, the combination therapy suppressed tumour angiogenesis by reducing the expression of VEGF in a synergistic manner, retarding the growth of the melanoma. Our study revealed that triptolide could significantly enhance the antitumour effect of VNP20009 by modulating tumour angiogenesis and the host immune response, providing a new understanding of the strategy to improve Salmonella-mediated tumour therapy.
- Subjects :
- 0301 basic medicine
Vascular Endothelial Growth Factor A
Salmonella
Combination therapy
Angiogenesis
Neutrophils
Medicine (miscellaneous)
medicine.disease_cause
03 medical and health sciences
chemistry.chemical_compound
Necrosis
0302 clinical medicine
Immune system
melanoma
Medicine
Animals
Colonization
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Salmonella-mediated tumor therapy
Neovascularization, Pathologic
business.industry
Mechanism (biology)
Melanoma
Triptolide
Phenanthrenes
medicine.disease
angiogenesis
Combined Modality Therapy
Biological Therapy
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
Treatment Outcome
chemistry
030220 oncology & carcinogenesis
Cancer research
Epoxy Compounds
Diterpenes
business
Immunosuppressive Agents
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 18387640
- Volume :
- 7
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Theranostics
- Accession number :
- edsair.doi.dedup.....3dd19cbca04a36c127f691b3bea4f489