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Budget impact model of a 5-grass sublingual immunotherapy tablet for the treatment of grass pollen-induced allergic rhinitis
- Source :
- Journal of Medical Economics. 18:909-918
- Publication Year :
- 2015
- Publisher :
- Informa Healthcare, 2015.
-
Abstract
- Allergic rhinitis (AR) is a chronic disease with a substantial clinical and economic burden. This study estimated the potential budget impact (BI) associated with market entry of Sweet Vernal, Orchard, Perennial Rye, Timothy, and Kentucky Blue Grass Mixed Pollens Allergen Extract Tablet for Sublingual Use ('5-grass SLIT tablet') for patients aged 10-65 with grass pollen-induced AR.A budget impact model was constructed to estimate the potential BI from a US payer perspective. The model calculated pharmacy, medical, and total (pharmacy + medical) costs per-member-per-month (PMPM) with and without market entry of the 5-grass SLIT tablet, considering a 3-year time horizon. The target population was determined using an epidemiological approach and existing literature. The treatment market shares without 5-grass SLIT tablet entry were derived from an analysis of de-identified insurance claims data. Pharmacy costs and medical utilization rates and costs were obtained from the claims data analysis and existing literature. One-way sensitivities were conducted for key model inputs.Using an illustrative example of a hypothetical health plan with one million members, the estimated target population of AR patients aged 10-65 was 26,320. On a PMPM basis, pharmacy costs increased by $0.36, $0.44, and $0.51, while total costs (after medical cost offsets) increased by $0.15, $0.18, and $0.22 in the first, second, and third years following entry of the 5-grass SLIT tablet, respectively. Results were most sensitive to changes in the compliance rate, treatment duration, and price. The BI will vary from the base case example when alternative, payer-specific inputs are used.Using base case inputs, use of the 5-grass SLIT tablet to treat grass pollen-induced AR increased the pharmacy budget for a hypothetical third-party payer. Higher pharmacy costs were partially offset by lower medical budget due to reduced resource use compared with existing treatments.
- Subjects :
- Adult
Male
Sublingual use
Allergen immunotherapy
Adolescent
Pharmacy
Target population
Poaceae
Kentucky blue-grass
Toxicology
Young Adult
Grass pollen
Fees, Pharmaceutical
otorhinolaryngologic diseases
Humans
Medicine
Computer Simulation
Sublingual immunotherapy
Child
health care economics and organizations
Aged
Sublingual Immunotherapy
business.industry
Health Policy
Rhinitis, Allergic, Seasonal
food and beverages
Budget impact
Health Services
Middle Aged
Immunology
Costs and Cost Analysis
Female
business
Models, Econometric
Tablets
Subjects
Details
- ISSN :
- 1941837X and 13696998
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Economics
- Accession number :
- edsair.doi.dedup.....3da99857e6e2557bef905bdb999800f9