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The dog as a genetic model for immunoglobulin A (IgA) deficiency: Identification of several breeds with low serum IgA concentrations
- Source :
- Veterinary Immunology and Immunopathology. 160:255-259
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Immunoglobulin A (IgA) serves as the basis of the secretory immune system by protecting the lining of mucosal sites from pathogens. In both humans and dogs, IgA deficiency (IgAD) is associated with recurrent infections of mucosal sites and immune-mediated diseases. Low concentrations of serum IgA have previously been reported to occur in a number of dog breeds but no generally accepted cut-off value has been established for canine IgAD. The current study represents the largest screening to date of IgA in dogs in terms of both number of dogs (n=1267) and number of breeds studied (n=22). Serum IgA concentrations were quantified by using capture ELISA and were found to vary widely between breeds. We also found IgA to be positively correlated with age (p
- Subjects :
- Male
Immunoglobulin A
Immunology
Golden Retriever
Biology
Dogs
Immune system
Species Specificity
Reference Values
Genetic model
medicine
Animals
Humans
Dog Diseases
Immunodeficiency
Models, Genetic
General Veterinary
IgA Deficiency
Atopic dermatitis
Nova Scotia Duck-Tolling Retriever
medicine.disease
biology.protein
Labrador Retriever
Female
Subjects
Details
- ISSN :
- 01652427
- Volume :
- 160
- Database :
- OpenAIRE
- Journal :
- Veterinary Immunology and Immunopathology
- Accession number :
- edsair.doi.dedup.....3da69f2dd7ddd13631d2908b3666ba2d
- Full Text :
- https://doi.org/10.1016/j.vetimm.2014.05.010