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The dog as a genetic model for immunoglobulin A (IgA) deficiency: Identification of several breeds with low serum IgA concentrations

Authors :
Kerstin Bergvall
Mia Olsson
Petra Roosje
Helene Hansson-Hamlin
Åke Hedhammar
Emma L. Ivansson
Tove Fall
Kerstin Lindblad-Toh
Katarina Tengvall
Marcel Frankowiack
Katarina Sundberg
Lennart Hammarström
Source :
Veterinary Immunology and Immunopathology. 160:255-259
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

Immunoglobulin A (IgA) serves as the basis of the secretory immune system by protecting the lining of mucosal sites from pathogens. In both humans and dogs, IgA deficiency (IgAD) is associated with recurrent infections of mucosal sites and immune-mediated diseases. Low concentrations of serum IgA have previously been reported to occur in a number of dog breeds but no generally accepted cut-off value has been established for canine IgAD. The current study represents the largest screening to date of IgA in dogs in terms of both number of dogs (n=1267) and number of breeds studied (n=22). Serum IgA concentrations were quantified by using capture ELISA and were found to vary widely between breeds. We also found IgA to be positively correlated with age (p

Details

ISSN :
01652427
Volume :
160
Database :
OpenAIRE
Journal :
Veterinary Immunology and Immunopathology
Accession number :
edsair.doi.dedup.....3da69f2dd7ddd13631d2908b3666ba2d
Full Text :
https://doi.org/10.1016/j.vetimm.2014.05.010