Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

Stress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRFWe miniaturized a cell-based assay, where CRFBP(10kD) is fused as a chimera with CRFWe found that CRFBP(10kD) potentiates CRF-intracellular CaThese results provide the first evidence of specific roles for CRF