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Investigating the association between serum human papillomavirus type 16 E7 antibodies and risk of head and neck cancer
- Source :
- Cancer Medicine, Cancer Medicine, Vol 10, Iss 12, Pp 4075-4086 (2021)
- Publication Year :
- 2021
-
Abstract
- Human papillomavirus (HPV) is recognized as a major cause of oropharyngeal cancer (OPC) in Western countries. Less is known regarding its contribution to the OPC occurring in Asia. The current study aimed to investigate the association between antibody responses to HPV16 E7 and head and neck cancer (HNC) risk in a hospital‐based case–control study conducted in Taiwan with 693 HNC cases and 1,035 controls. A positive association was observed between seropositivity to HPV16 E7 and OPC risk, whereas no significant association was found in the non‐OPC cases. The increased OPC risk associated with seropositivity to HPV16 E7 was more significant among nonbetel quid or noncigarette users. Seropositivity to HPV16 E7 showed moderate agreement with P16 expression in OPC. OPC patients that were seropositive to HPV16 E7 or p16 positive were more highly educated and less likely to use alcohol, betel quids, and cigarettes compared to HPV16 E7 seronegative or p16 negative OPC patients. Furthermore, patients with p16 positive OPC were more likely to be women compared to patients with p16 negative OPC, likely owing to the low prevalence of alcohol, betel quid, and cigarette users among women. Overall, this study suggested that similar to Western countries, HPV may also be an important risk factor of OPC in Taiwan. With the declining consumption of betel quids and cigarettes in Taiwan, a higher percentage of OPC cases in Taiwan will be attributed to HPV in the future. Public health measures, including HPV vaccination, need to be implemented to prevent the occurrence of HPV‐positive OPC.<br />The current study found a a positive association between seropositivity to HPV16 E7 and oropharyngeal cancer risk. This study suggested that similar to Western countries, HPV may also be an important risk factor of OPC in Taiwan.
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Papillomavirus E7 Proteins
Antibodies, Viral
0302 clinical medicine
cancer risk factors
Risk Factors
Epidemiology
RC254-282
Original Research
Human papillomavirus 16
biology
Smoking
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
virus diseases
Middle Aged
Betel
Oropharyngeal Neoplasms
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Female
epidemiology
Antibody
Cancer Prevention
medicine.medical_specialty
Alcohol Drinking
Taiwan
03 medical and health sciences
Sex Factors
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Risk factor
Areca
Cancer prevention
business.industry
Public health
Head and neck cancer
Cancer
medicine.disease
biology.organism_classification
stomatognathic diseases
030104 developmental biology
nervous system
Case-Control Studies
biology.protein
head and neck cancer
business
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 10
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Cancer medicine
- Accession number :
- edsair.doi.dedup.....3d97ad9998a1dbd9795b9d5a0cda0281