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Diagnostic algorithms for non-ST-segment elevation myocardial infarction: open issues
- Source :
- Clinical Chemistry and Laboratory Medicine (CCLM). 59:1761-1771
- Publication Year :
- 2021
- Publisher :
- Walter de Gruyter GmbH, 2021.
-
Abstract
- The use of serial measurement of cardiac troponin (cTn) is recommended by international guidelines for the diagnosis of myocardial infarction (MI) since 2000. This article focuses on factors influencing temporal changes in high-sensitive cTn (hs)-cTn and the impact of these factors on the diagnosis of non-ST-segment elevation MI (NSTEMI). The recommendations proposed by three different international guidelines published in 2020–2021 for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation (NSTE) show some discrepancies. In particular, there is no agreement among these guidelines about cut-off or absolute change values to be used for the rule-in, especially regarding the use of sex-specific cut-off values. Furthermore, there are no sufficient evidences on the diagnostic accuracy and cost effectiveness related to cut-off values suggested for algorithms to be used by some hs-cTnI methods.
- Subjects :
- cardiovascular risk
Male
medicine.medical_specialty
Cardiac troponin
Cost effectiveness
high-sensitivity immunoassay
Clinical Biochemistry
Myocardial Infarction
Diagnostic accuracy
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
reference population
Troponin T
Internal medicine
cardiac troponins
medicine
Humans
ST segment
guidelines
quality specification
030212 general & internal medicine
Myocardial infarction
Acute Coronary Syndrome
Non-ST Elevated Myocardial Infarction
health care economics and organizations
business.industry
Troponin I
Biochemistry (medical)
Elevation
Diagnostic algorithms
General Medicine
medicine.disease
Cardiology
Female
Absolute Change
business
Algorithms
Biomarkers
Subjects
Details
- ISSN :
- 14374331 and 14346621
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Accession number :
- edsair.doi.dedup.....3d91fa3d9832289758f514ce7aa95905