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Intraoperative measurements of cerebral haemodynamics during ductus arteriosus ligation in preterm infants
- Source :
- European Journal of Pediatrics. 150:362-365
- Publication Year :
- 1991
- Publisher :
- Springer Science and Business Media LLC, 1991.
-
Abstract
- Intraoperative Doppler sonographic examinations were carried out on seven preterm neonates to measure cerebral blood flow velocity changes in the anterior cerebral arteries during ductus arteriosus ligation. Age at surgery was 12 +/- 6 days. Continuous recordings during the operative procedure showed a rapid increase in diastolic blood pressure (P less than 0.01), whereas systolic blood pressure was not significantly higher compared with pre-occlusion values. In the anterior cerebral arteries, ductal closure led to a decrease in resistance index of Pourcelot (mean = 1.02 +/- 0.08 vs 0.65 +/- 0.07 (P less than 0.001)) and to an increase in area under the velocity curve (mean = 3.64 +/- 0.38 vs 8.16 +/- 1.07 (P less than 0.001)). These changes were associated with a corresponding increase of the end diastolic flow velocity (P less than 0.001) but no change in the peak systolic velocity. The heart rate did not change significantly during ductal closure. TcPO2, TcPCO2 remained normal during the study period. These data indicate that changes in cerebral blood flow velocity during surgical ligation are principally determined by changes in systemic diastolic pressure. Systolic blood pressure and peak systolic flow velocity remain unchanged or slightly higher than preligation values, thereby restoring normal cerebral blood flow velocity pattern without increasing the stress on the wall of cerebral vessels and thus the risk of peri-intraventricular haemorrhage.
- Subjects :
- business.industry
Cerebral arteries
Infant, Newborn
Blood Pressure
Infant, Premature, Diseases
Intraoperative Period
medicine.anatomical_structure
Blood pressure
Cerebral blood flow
Flow velocity
Cerebrovascular Circulation
Ductus arteriosus
Anesthesia
Pediatrics, Perinatology and Child Health
Heart rate
medicine
Humans
Arterial blood
business
Ductus Arteriosus, Patent
Ligation
Blood Flow Velocity
Ultrasonography
Artery
Subjects
Details
- ISSN :
- 14321076 and 03406199
- Volume :
- 150
- Database :
- OpenAIRE
- Journal :
- European Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....3d91555249b388efa18af329b016a591