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The Implication of Vitamin D and Autoimmunity: a Comprehensive Review
- Source :
- Clinical Reviews in Allergy & Immunology. 45:217-226
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Historically, vitamin D has been associated with the regulation of bone metabolism. However, increasing evidence demonstrates a strong association between vitamin D signaling and many biological processes that regulate immune responses. The discovery of the vitamin D receptor in multiple immune cell lineages, such as monocytes, dendritic cells, and activated T cells credits vitamin D with a novel role in modulating immunological functions and its subsequent role in the development or prevention of autoimmune diseases. In this review we, discuss five major areas in vitamin D biology of high immunological significance: (1) the metabolism of vitamin D; (2) the significance of vitamin D receptor polymorphisms in autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; (3) vitamin D receptor transcriptional regulation of immune cell lineages, including Th1, Th17, Th2, regulatory T, and natural killer T cells; (4) the prevalence of vitamin D insufficiency/deficiency in patients with multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; and finally, (5) the therapeutic effects of vitamin D supplementation on disease severity and progression.
- Subjects :
- Diet therapy
Biology
medicine.disease_cause
Calcitriol receptor
Article
Autoimmune Diseases
Autoimmunity
Immune system
T-Lymphocyte Subsets
medicine
Vitamin D and neurology
Animals
Humans
Immunology and Allergy
Cell Lineage
Genetic Predisposition to Disease
Vitamin D
Type 1 diabetes
Polymorphism, Genetic
Multiple sclerosis
Cell Differentiation
General Medicine
Th1 Cells
Vitamin D Deficiency
medicine.disease
Natural killer T cell
Gene Expression Regulation
Immunology
Receptors, Calcitriol
Diet Therapy
Subjects
Details
- ISSN :
- 15590267 and 10800549
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Clinical Reviews in Allergy & Immunology
- Accession number :
- edsair.doi.dedup.....3d8b1ee105bd07b0114d0fde55b84f36