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Toward a better understanding of gastrointestinal nitrergic neuromuscular transmission
- Source :
- Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 26(7)
- Publication Year :
- 2014
-
Abstract
- Background Nitric oxide (NO) is an important inhibitory neurotransmitter in the gastrointestinal (GI) tract. The majority of nitrergic effects are transduced by NO-sensitive guanylyl cyclase (NO-GC) as the receptor for NO, and, thus, mediated by cGMP-dependent mechanisms. Work carried out during the past years has demonstrated NO to be largely involved in GI smooth muscle relaxation and motility. However, detailed investigation of nitrergic signaling has turned out to be complicated as NO-GC was identified in several different GI cell types such as smooth muscle cells, interstitial cells of Cajal and fibroblast-like cells. With regards to nitrergic neurotransmission, special focus has been placed on the role of interstitial cells of Cajal using mutant mice with reduced populations of ICC. Recently, global and cell-specific knockout mice for enzymes participating in nitrergic signaling have been generated providing a suitable approach to further examine the role of NO-mediated signaling in GI smooth muscle. Purpose This review discusses the current knowledge on nitrergic mechanisms in gastrointestinal neuromuscular transmission with a focus on genetic models and outlines possible further investigations to gain better understanding on NO-mediated effects in the GI tract.
- Subjects :
- Cell type
medicine.medical_specialty
Physiology
Myocytes, Smooth Muscle
Neuromuscular transmission
Neuromuscular Junction
Motility
Receptors, Cytoplasmic and Nuclear
Biology
Nitric Oxide
Synaptic Transmission
Nitric oxide
chemistry.chemical_compound
symbols.namesake
Mice
Soluble Guanylyl Cyclase
Internal medicine
Genetic model
medicine
Animals
Receptor
Cyclic GMP
Endocrine and Autonomic Systems
Gastroenterology
Muscle, Smooth
Interstitial Cells of Cajal
Interstitial cell of Cajal
Gastrointestinal Tract
Endocrinology
chemistry
Guanylate Cyclase
Knockout mouse
symbols
Neuroscience
Subjects
Details
- ISSN :
- 13652982
- Volume :
- 26
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
- Accession number :
- edsair.doi.dedup.....3d82bd7b37de92cd78078b3d943d157f