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Human Parechovirus 1, 3 and 4 Neutralizing Antibodies in Dutch Mothers and Infants and Their Role in Protection Against Disease

Authors :
Dasja Pajkrt
Eveliina Karelehto
Katja C. Wolthers
Gerrit Koen
Menno D. de Jong
Joanne G. Wildenbeest
Sjoerd Rebers
Brenda M. Westerhuis
Kimberley S. M. Benschop
Saskia Bouma-de Jongh
AII - Infectious diseases
Graduate School
Medical Microbiology and Infection Prevention
Amsterdam Reproduction & Development (AR&D)
General Paediatrics
Paediatric Infectious Diseases / Rheumatology / Immunology
Source :
The Pediatric Infectious Disease Journal, Pediatric infectious disease journal, 37(12), 1304-1308. Lippincott Williams and Wilkins, The Pediatric infectious disease journal, 37(12), 1304. Lippincott Williams and Wilkins
Publication Year :
2018
Publisher :
Williams & Wilkins, 2018.

Abstract

Supplemental Digital Content is available in the text.<br />Background: Human parechoviruses (HPeVs) are common pathogens in young children, and in the Netherlands, HPeV1, HPeV3 and HPeV4 are the most frequently detected genotypes. HPeV3 in particular has been associated with severe disease in young infants below 3 months of age while the other genotypes more often infect older children and elicit mild symptoms. We investigated if maternal neutralizing antibodies (nAbs) against HPeV1, HPeV3 and HPeV4 protect young Dutch infants from severe disease related to HPeV infection. Methods: We conducted a prospective case–control study of Dutch mother–infant pairs. Thirty-eight HPeV-infected infants and their mothers were included as cases, and 65 HPeV-negative children and their mothers as controls. Results: In control infants, we observed nAb seropositivity rates of 41.4%, 33.3% and 27.6%, with median nAb titers of 1:16, 1:12 and 1:8, against HPeV1, HPeV3 and HPeV4, respectively. In control mothers, nAb seropositivity rates were 84.6%, 55.4% and 60.0% with median nAb titers of 1:128, 1:32 and 1:45 against HPeV1, HPeV3 and HPeV4, respectively. The HPeV3 nAb seroprevalence was significantly lower in HPeV3-infected infants and their mothers (0.0% with P < 0.05 and 10.0% with P < 0.001, respectively). In contrast, no differences in nAb seroprevalence against HPeV1 or HPeV4 could be detected between case and control infants or mothers. Conclusions: Our results suggest that young Dutch infants are protected against severe disease related to HPeV1 and HPeV4 by maternal nAbs, but less so against HPeV3 explaining the distinct age distributions and disease severity profiles of children infected with these HPeV genotypes.

Details

Language :
English
ISSN :
15320987 and 08913668
Volume :
37
Issue :
12
Database :
OpenAIRE
Journal :
The Pediatric Infectious Disease Journal
Accession number :
edsair.doi.dedup.....3d7eda16a1500cdb721ac827403abdee