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Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer
- Source :
- BMC Cancer, BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)
- Publication Year :
- 2019
- Publisher :
- BioMed Central, 2019.
-
Abstract
- Background Despite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and proliferation play a significant role in malignancies. In terms of colorectal cancer, the impact of proliferation associated proteins is controversially debated. The aim of our study was to examine the expression of topoisomerase II α and minichromosome maintenance protein 6 and to correlate these findings with the clinical data. Methods Tissue samples of 619 patients in total were stained using the antibodies Ki-S4 and Ki-MCM6 targeting topoisomerase II α as well as minichromosome maintenance protein 6. The median rate of proliferation was correlated with clinical and follow up data. Results The expression rate of minichromosome maintenance protein 6 is significantly higher than the proportion of topoisomerase II α in tumour cells (p
- Subjects :
- 0301 basic medicine
Male
Cancer Research
Cell division
Colorectal cancer
Colon
Topoisomerase II α
lcsh:RC254-282
Topoisomerase ii α
Disease-Free Survival
Proliferative proteins
03 medical and health sciences
0302 clinical medicine
Prognostic marker
Minichromosome maintenance
Surgical oncology
Genetics
Biomarkers, Tumor
Medicine
Humans
Poly-ADP-Ribose Binding Proteins
Aged
Cell Proliferation
Retrospective Studies
Minichromosome maintenance protein 6
biology
business.industry
Rectum
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Clinical routine
medicine.disease
Prognosis
Minichromosome Maintenance Complex Component 6
Survival Analysis
030104 developmental biology
DNA Topoisomerases, Type II
Oncology
030220 oncology & carcinogenesis
Cancer research
biology.protein
Female
Antibody
business
Colorectal Neoplasms
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....3d7d0f145f80439aa441f19da748b231