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HPLC Analysis and Skin Whitening Effects of Umbelliprenin-containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris
- Source :
- Molecules, Molecules, MDPI, 2019, 24 (3), pp.501. ⟨10.3390/molecules24030501⟩, Molecules, Vol 24, Iss 3, p 501 (2019), Molecules, 2019, 24 (3), pp.501. ⟨10.3390/molecules24030501⟩
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Umbelliprenin has recently been shown to have great potential as a skin whitening agent. Wishing to investigate the same effect in plant species known to biosynthesize this coumarin, three plants belonging to the Apiaceae family, namely Anethum graveolens L. (dill), Pimpinella anisum L. (anise), and Ferulago campestris (Besser) Grecescu (field ferula) were screened by HPLC analysis for their respective content of umbelliprenin in extracts obtained with different solvent mixtures and by maceration and ultrasound-assisted processes. EtOH was shown to be the best solvent, providing umbelliprenin yields ranging from 1.7% to 14.4% (with respect to the total amount of extract obtained). Extracts with the highest content of this farnesyloxycoumarin were then assayed as modulators of melanogenesis in cultured murine Melan A cells employing the same umbelliprenin obtained by chemical synthesis as the reference. A parallelism between the content of the coumarin and the recorded depigmenting effect (60% for the EtOH extract of F. campestris as the best value) was revealed for all plants extracts when applied at a dose of 100 μg/mL. Our results demonstrate that the same potential of umbelliprenin can be ascribed also to umbelliprenin-enriched plant extracts which reinforces enforce the widespread use of phyto-preparations for cosmetic purposes (e.g., A. graveolens).
- Subjects :
- melanogenesis
[SDV]Life Sciences [q-bio]
Pharmaceutical Science
umbelliprenin
01 natural sciences
dill
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Pimpinella anisum
Drug Discovery
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Maceration (wine)
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
Physical and Theoretical Chemistry
[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
Apiaceae
biology
Traditional medicine
010405 organic chemistry
Organic Chemistry
Anethum graveolens
Skin whitening
biology.organism_classification
Coumarin
Ferulago campestris
melanin
oxyprenylated coumarins
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
0104 chemical sciences
Umbelliprenin
[SDV] Life Sciences [q-bio]
skin whitening effect
010404 medicinal & biomolecular chemistry
chemistry
Chemistry (miscellaneous)
field ferula
Molecular Medicine
apiaceae
anise
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....3d7c6077ae30161cae29eba23ebc6820
- Full Text :
- https://doi.org/10.3390/molecules24030501