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Alterations in epidermal function in type 2 diabetes: Implications for the management of this disease
- Source :
- Journal of diabetes, vol 14, iss 9
- Publication Year :
- 2022
- Publisher :
- eScholarship, University of California, 2022.
-
Abstract
- Epidermal function is regulated by numerous exogenous and endogenous factors, including age, psychological stress, certain skin disorders, ultraviolet irradiation and pollution, and epidermal function itself can regulate cutaneous and extracutaneous functions. The biophysical properties of the stratum corneum reflect the status of both epidermal function and systemic conditions. Type 2 diabetes in both murine models and humans displays alterations in epidermal functions, including reduced levels of stratum corneum hydration and increased epidermal permeability as well as delayed permeability barrier recovery, which can all provoke and exacerbate cutaneous inflammation. Because inflammation plays a pathogenic role in type 2 diabetes, a therapy that improves epidermal functions could be an alternative approach to mitigating type 2 diabetes and its associated cutaneous disorders.表皮功能受到多种外源性和内源性因素的调节,包括年龄、心理应激、某些皮肤病、紫外线照射和污染,而表皮本身也可以调节皮肤和皮外的功能。角质层的生物和物理性质反映了表皮功能和全身状况。在小鼠模型和人类中,2型糖尿病都表现出表皮功能的变化,包括角质层水合作用水平降低、表皮渗透性增加、以及通透性屏障恢复延迟,这些都可以引发和加剧皮肤炎症。由于炎症在2型糖尿病中起致病作用,因此改善表皮功能的治疗可能是缓解2型糖尿病及其相关皮肤疾病的替代方法。.
- Subjects :
- keratinocytes
stratum corneum hydration
Endocrinology, Diabetes and Metabolism
1.1 Normal biological development and functioning
Clinical Sciences
衰老
Permeability
糖尿病
通透性屏障
Mice
Underpinning research
Diabetes Mellitus
Animals
Humans
2.1 Biological and endogenous factors
Aetiology
Metabolic and endocrine
Skin
permeability barrier
Inflammation
diabetes
aging
cytokines
细胞因子
Diabetes Mellitus, Type 2
角质层水化作用。
Public Health and Health Services
角质形成细胞
Epidermis
Type 2
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of diabetes, vol 14, iss 9
- Accession number :
- edsair.doi.dedup.....3d7525d8784481b8d66b6bb06cd48699