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Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases
- Source :
- CNS Neuroscience & Therapeutics. 23:921-929
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- In this review, we summarize the involvement of ascorbic acid in neurodegenerative diseases by presenting available evidence on the behavioral and biochemical effects of this compound in animal models of neurodegeneration as well as the use of ascorbic acid as a therapeutic approach to alleviate neurodegenerative progression in clinical studies. Ascorbate, a reduced form of vitamin C, has gained interest for its multiple functions and mechanisms of action, contributing to the homeostasis of normal tissues and organs as well as to tissue regeneration. In the brain, ascorbate exerts neuromodulatory functions and scavenges reactive oxygen species generated during synaptic activity and neuronal metabolism. These are important properties as redox imbalance and abnormal protein aggregation constitute central mechanisms implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, multiple sclerosis, and amyotrophic lateral sclerosis. Indeed, several studies have indicated an association between low serum ascorbate concentrations and neurodegeneration. Moreover, ascorbic acid is a suitable candidate for supplying either antioxidant defense or modulation of neuronal and astrocytic metabolism under neurodegenerative conditions. Ascorbic acid acts mainly by decreasing oxidative stress and reducing the formation of protein aggregates, which may contribute to the reduction of cognitive and/or motor impairments observed in neurodegenerative processes. Although several studies support a possible role of ascorbic acid administration against neurodegeneration, more researches are essential to substantiate the existing results and accelerate the knowledge in this field.
- Subjects :
- 0301 basic medicine
Antioxidant
medicine.medical_treatment
Ascorbic Acid
Review Article
Pharmacology
Protein aggregation
medicine.disease_cause
Antioxidants
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Humans
Medicine
Pharmacology (medical)
Amyotrophic lateral sclerosis
chemistry.chemical_classification
Reactive oxygen species
Vitamin C
business.industry
Neurodegeneration
Neurodegenerative Diseases
Ascorbic acid
medicine.disease
Psychiatry and Mental health
030104 developmental biology
chemistry
business
Neuroscience
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 17555930
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- CNS Neuroscience & Therapeutics
- Accession number :
- edsair.doi.dedup.....3d65c54c1a0452de57da21f47da71a07