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Hospital-diagnosed overweight and obesity related to cancer risk:a 40-year Danish cohort study
- Source :
- Gribsholt, S B, Cronin-Fenton, D, Veres, K, Thomsen, R W, Ording, A G, Richelsen, B & Sørensen, H T 2020, ' Hospital-diagnosed overweight and obesity related to cancer risk : a 40-year Danish cohort study ', Journal of Internal Medicine, vol. 287, no. 4, pp. 435-447 . https://doi.org/10.1111/joim.13013
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: Obesity is associated with metabolic abnormalities that predispose patients to increased cancer risk. Contemporary data on the long-term risk of specific cancers are sparse among patients with hospital-diagnosed overweight and obesity.OBJECTIVES: To examine the overall cancer incidence and specific site-related cancer incidences among patients with overweight and obesity, compared to the general Danish population.METHODS: For this 40-year (1977-2016), nationwide, Danish cohort study, we reviewed medical databases to identify individuals with hospital-based overweight and obesity diagnoses. We computed age- and gender-standardized incidence ratios (SIRs) for subsequent cancer compared to the general population.RESULTS: We observed 20 706 cancers among 313 321 patients diagnosed with overweight and obesity (median age 43 years; median follow-up 6.7 years, range 1-40 years) compared to the 18 480 cancers expected; thus, the SIR was 1.12 [95% confidence interval (95% CI): 1.11-1.14]. The SIR associated with overweight and obesity was increased with concomitant comorbidities, like type 2 diabetes (SIR: 1.18; 95% CI: 1.13-1.23) and alcoholism-related diseases (SIR: 1.62; 95% CI: 1.45-1.82). The SIR was 1.31 (95% CI: 1.28-1.34) for cancers previously identified as obesity-related, including pancreatic (SIR: 1.38; 95% CI; 1.27-1.49) and postmenopausal breast cancer (SIR: 1.14; 95% CI: 1.09-1.19). Obesity/overweight status also elevated the SIRs for haematological (SIR: 1.24; 95% CI: 1.18-1.29) and neurological cancers (SIR: 1.19; 95% CI: 1.11-1.27]. In contrast, SIRs were 1.01 (95% CI: 0.97-1.05) for immune-related cancers, 0.88 (95% CI: 0.82-0.95) for malignant melanoma, and 0.88 (95% CI: 0.85-0.92) for hormone-related cancers, other than postmenopausal breast cancer.CONCLUSION: In this large cohort study, overweight and obesity was associated with increased risk of several common cancers.
- Subjects :
- 0301 basic medicine
Male
obesity
Denmark
Type 2 diabetes
Comorbidity
030204 cardiovascular system & hematology
Overweight
MALIGNANT-MELANOMA
0302 clinical medicine
Risk Factors
Neoplasms
Registries
Child
education.field_of_study
Incidence (epidemiology)
Incidence
Smoking
Middle Aged
ICD-10 DIAGNOSES
Hospitalization
NATIONAL REGISTRY
Child, Preschool
Female
epidemiology
medicine.symptom
DATA QUALITY
Cohort study
Adult
medicine.medical_specialty
Adolescent
Alcohol Drinking
Population
03 medical and health sciences
Young Adult
Breast cancer
Internal medicine
Internal Medicine
medicine
Humans
cancer
overweight
Obesity
education
METAANALYSIS
Aged
Retrospective Studies
business.industry
Infant, Newborn
Cancer
Infant
medicine.disease
BODY-MASS INDEX
030104 developmental biology
Case-Control Studies
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Gribsholt, S B, Cronin-Fenton, D, Veres, K, Thomsen, R W, Ording, A G, Richelsen, B & Sørensen, H T 2020, ' Hospital-diagnosed overweight and obesity related to cancer risk : a 40-year Danish cohort study ', Journal of Internal Medicine, vol. 287, no. 4, pp. 435-447 . https://doi.org/10.1111/joim.13013
- Accession number :
- edsair.doi.dedup.....3d40f329ad953ffa73e2a35db4462b85