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Effective Treatment of Indolent Non-Hodgkin’s Lymphomas with Mitoxantrone, Chlorambucil and Prednisone
- Source :
- Oncology Research and Treatment. 28:73-78
- Publication Year :
- 2005
- Publisher :
- S. Karger AG, 2005.
-
Abstract
- Since indolent non-Hodgkin's lymphomas (NHL) represent about 35% of all malignant lymphomas and mainly affect elderly patients, availability of a conventional chemotherapy regimen with high efficacy and low toxicity is of clinical importance.We retrospectively analysed 13 patients with advanced indolent NHL who were treated with 6-9 cycles of MCP: mitoxantrone 8 mg/m2 (days 1 and 2), chlorambucil 3 x 3 mg/m2 (days 1-5) and prednisone 25 mg (days 1-5) every 4 weeks.The overall response was 84% (61% complete response, 23% partial response), 1 patient had stable disease and 1 patient experienced progressive disease. Median time to progression was 37 months (95% CI: 20-53) and the median survival has not yet been reached. The main toxicity (66%) was neutropenia (WHO grade III). There was no hair loss and no cardial or neurologic adverse event.In summary, MCP is an effective and well tolerated chemotherapy regimen and is probably an alternative to the more toxic CHOP regimen, especially in older patients.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Neutropenia
Prednisolone
Antineoplastic Agents
Severity of Illness Index
Disease-Free Survival
immune system diseases
Prednisone
hemic and lymphatic diseases
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Effective treatment
Aged
Retrospective Studies
Mitoxantrone
Hodgkin s
Chlorambucil
business.industry
Lymphoma, Non-Hodgkin
Hematology
Middle Aged
medicine.disease
Regimen
Treatment Outcome
Immunology
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 22965262 and 22965270
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Oncology Research and Treatment
- Accession number :
- edsair.doi.dedup.....3d405e573fb5c8a5773c101be02afec9