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Insecticidal activity of the pyrimidine nucleoside analogue (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU)
- Source :
- Pest Management Science. 61:737-741
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- The insecticidal activity of the antiherpetic agent (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) was assessed in in vivo assays against the fall armyworm, Spodoptera frugiperda (JE Smith) (Lepidoptera, Noctuidae). BVDU, mixed into an artificial diet, caused a variety of effects, depending on the concentration used. Compared with controls, food intake was lower, larval growth was retarded and larval development was prolonged. The treated larvae formed smaller pupae and the hatching moths often showed morphogenetic defects. A higher mortality could be found in larval and pupal stages and was generally caused by moult disruption. A choice assay showed that BVDU has very slight feeding-deterrent properties, which only partly explain the toxic effects. The agent most probably acts through its cytostatic activity that has been described previously using cell lines of different insect species.
- Subjects :
- Insecticides
animal structures
Spodoptera
Lepidoptera genitalia
chemistry.chemical_compound
In vivo
medicine
Animals
Dose-Response Relationship, Drug
Molecular Structure
biology
Nucleoside analogue
fungi
Pupa
Biological activity
General Medicine
biology.organism_classification
Molecular biology
Deoxyuridine
Bromodeoxyuridine
Biochemistry
chemistry
Larva
Insect Science
Noctuidae
Agronomy and Crop Science
Nucleoside
medicine.drug
Subjects
Details
- ISSN :
- 15264998 and 1526498X
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Pest Management Science
- Accession number :
- edsair.doi.dedup.....3d3831927eb320ea3a5096cd37ea5e11