Back to Search
Start Over
Limbic neurochemical changes in patients with functional motor symptoms
- Publication Year :
- 2019
-
Abstract
- ObjectiveTo assess by magnetic resonance spectroscopy (MRS) the N-acetylaspartate, myo-inositol, choline, sum of glutamate and glutamine (Glx), and creatine (Cr) content in the anterior cingulate cortex (ACC)/medial prefrontal cortex (mPFC) and in the occipital cortex (OCC) (control region) in patients with functional motor symptoms (FMS) and healthy controls, and to determine whether neurochemical limbic changes as estimated by MRS correlate with FMS-related motor symptom severity, alexithymia, anxiety, depression, and quality of life.MethodsThis case-control study enrolled 10 patients with FMS and 10 healthy controls. Participants underwent MRS and were tested with the Mini-Mental State Examination, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, 20-Item Toronto Alexithymia Scale, and EuroQol 5D.ResultsIn patients with FMS, MRS showed increased Glx/Cr in the ACC/mPFC but normal content in the control OCC. All the other metabolites tested were normal in both regions. The increased Glx/Cr content in the ACC/mPFC correlated with alexithymia, anxiety, and severity of symptoms.ConclusionsThe abnormal limbic Glx increase could have a crucial pathophysiologic role in FMS, possibly by altering limbic-motor interactions, ultimately leading to abnormal movements.
- Subjects :
- Male
functional motor symptoms
limbic circuit
Magnetic Resonance Spectroscopy
Hamilton Anxiety Rating Scale
Glutamine
Anxiety
Severity of Illness Index
Toronto Alexithymia Scale
0302 clinical medicine
Alexithymia
Cortex (anatomy)
Limbic System
Prefrontal cortex
functional motor symptom
Movement Disorders
medicine.diagnostic_test
Affective Symptom
Depression
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
Adult
Affective Symptoms
Case-Control Studies
Creatine
Female
Glutamic Acid
Humans
Quality of Life
medicine.symptom
Case-Control Studie
Human
medicine.medical_specialty
03 medical and health sciences
Neurochemical
Internal medicine
medicine
Movement Disorder
Anterior cingulate cortex
business.industry
medicine.disease
030227 psychiatry
Endocrinology
nervous system
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....3d37600463e4c683bb8f320d6f23e234